We protect your health through science
Investigation
Human viruses of the herpesviridae family
Publications
Leon KE, Schubert RD, Casas-Alba D, Hawes IA, Ramachandran PS, Ramesh A, Pak JE, Wu W, Cheung CK, Crawford ED, Khan LM, Launes C, Sample HA, Zorn KC, Cabrerizo M, Valero-Rello A, Langelier C, Muñoz-Almagro C, DeRisi JL, Wilson MR. Genomic and serologic characterization of enterovirus A71 brainstem encephalitis. Neurol Neuroimmunol Neuroinflamm. 2020
Leon KE, Schubert RD, Casas-Alba D, Hawes IA, Ramachandran PS, Ramesh A, Pak JE, Wu W, Cheung CK, Crawford ED, Khan LM, Launes C, Sample HA, Zorn KC, Cabrerizo M, Valero-Rello A, Langelier C, Muñoz-Almagro C, DeRisi JL, Wilson MR. Genomic and serologic characterization of enterovirus A71 brainstem encephalitis. Neurol Neuroimmunol Neuroinflamm. 2020 Mar 5;7(3):e703. doi: 10.1212/NXI.0000000000000703. PMID: 32139440; PMCID: PMC7136061.
González-Sanz R, Casas-Alba D, Launes C, Muñoz-Almagro C, Ruiz-García MM, Alonso M, González-Abad MJ, Megías G, Rabella N, Del Cuerpo M, Gozalo-Margüello M, González-Praetorius A, Martínez-Sapiña A, Goyanes-Galán MJ, Romero MP, Calvo C, Antón A, Imaz M, Aranzamendi M, Hernández-Rodríguez Á, Moreno-Docón A, Rey- Cao S, Navascués A, Otero A, Cabrerizo M. Molecular epidemiology of an enterovirus A71 outbreak associated with severe neurological disease, Spain, 2016. Euro Surveill. 2019
González-Sanz R, Casas-Alba D, Launes C, Muñoz-Almagro C, Ruiz-García MM, Alonso M, González-Abad MJ, Megías G, Rabella N, Del Cuerpo M, Gozalo-Margüello M, González-Praetorius A, Martínez-Sapiña A, Goyanes-Galán MJ, Romero MP, Calvo C, Antón A, Imaz M, Aranzamendi M, Hernández-Rodríguez Á, Moreno-Docón A, Rey- Cao S, Navascués A, Otero A, Cabrerizo M. Molecular epidemiology of an enterovirus A71 outbreak associated with severe neurological disease, Spain, 2016. Euro Surveill. 2019 Feb;24(7):1800089. doi: 10.2807/1560-7917.ES.2019.24.7.1800089. PMID: 30782267; PMCID: PMC6381658.
Spanish Afp Surveillance Working Group. Acute flaccid paralysis (AFP) surveillance: challenges and opportunities from 18 years' experience, Spain, 1998 to 2015. Euro Surveill.
Spanish Afp Surveillance Working Group. Acute flaccid paralysis (AFP) surveillance: challenges and opportunities from 18 years' experience, Spain, 1998 to 2015. Euro Surveill. 2018 Nov;23(47):1700423. doi: 10.2807/1560-7917.ES.2018.23.47.1700423. PMID: 30482263; PMCID: PMC6341937.
Molecular Epidemiology of Human Parechoviruses in Children With Acute Respiratory Infection in Spain
M Cabrerizo*, C Calvo, G Trallero, ML García-García, M Arroyas, V Sánchez, F Pozo, I Casas. Molecular epidemiology of human parechoviruses children with acute respiratory infection in Spain. Pediatric Infect Dis J 32:802-3 (2013).
PUBMED DOIIdentification of novel Betaherpesviruses in iberian bats reveals parallel evolution
Pozo F, Juste J, Vázquez-Morón S., Aznar-López C, Ibáñez C, Garin I, Aihartza J, Casa I, Tenorio A, Echevarría JE. Identification of novel Betaherpesviruses in iberian bats reveals parallel evolution. PLoS ONE. 2016. 11(12): e0169153. doi:10.1371/journal.pone.0169153
PUBMED DOIDetection of Rhabdovirus viral RNA in oropharyngeal swabs and ectoparasites of Spanish bats
Aznar C, Vazquez-Moron S, Martson D, Juste J, Ibáñez C, Berciano JM, Salsamendi E, Aihartza J, Banyard AC, McElhinney L, Fooks AR, Echevarria JE. Detection of Rhabdovirus viral RNA in oropharyngeal swabs and ectoparasites of Spanish bats. Journal of General Virology. 2013. 94: 69-75.
PUBMED DOIGenomic non-coding regions reveal hidden patterns of mumps virus circulation in Spain, 2005 to 2015
Gavilán AM, Fernández-García A*, Rueda A, Castellanos A, Masa J, López-Perea N, Torres de Mier MV, de Ory F, Echevarría JE. Non-coding sequences reveal hidden patterns of mumps virus circulation in Spain, 2005 to 2015. Eurosurveillance,2018, 23(15): 1-8. *Corresponding author.
PUBMED DOIFirst cases of European Bat Lyssavirus type 1 in Iberian serotine bats: implications for the molecular epidemiology of bat rabies in Europe.
Mingo-Casas P, Sandonís V, Obón E, Berciano JM, Vázquez-Morón S, Juste J, Echevarría JE. First cases of European Bat Lyssavirus type 1 in Iberian serotine bats: implications for the molecular epidemiology of bat rabies in Europe. Plos Neglected Tropical Diseases, 2018: 12(4): e0006290.
PUBMED DOILast cases of rubella and congenital rubella syndrome in Spain, 1997–2016: The success of a vaccination program
Seppälä EM, López-Perea N, Torres de Mier MV, Echevarría JE, Fernández García A, Masa-Calles J. Last cases of rubella and congenital rubella syndrome in Spain, 1997–2016: The success of a vaccination program. Vaccine, 2019, 37(1):169-175.
PUBMED DOICombination of Cefditoren and N-acetyl-l-Cysteine Shows a Synergistic Effect against Multidrug-Resistant Streptococcus pneumoniae Biofilms
Llamosí M, Sempere J, Coronel P, Gimeno M, Yuste J, Domenech M. Combination of Cefditoren and N-acetyl-l-Cysteine Shows a Synergistic Effect against Multidrug-Resistant Streptococcus pneumoniae Biofilms. Microbiol Spectr. 2022 Dec 21;10(6):e0341522
PUBMED DOIClearance of mixed biofilms of Streptococcus pneumoniae and methicillin-susceptible/resistant Staphylococcus aureus by antioxidants N-acetyl-L-cysteine and cysteamine
Sempere J, Llamosí M, Román F, Lago D, González-Camacho F, Pérez-García C, Yuste J, Domenech M. Clearance of mixed biofilms of Streptococcus pneumoniae and methicillin-susceptible/resistant Staphylococcus aureus by antioxidants N-acetyl-L-cysteine and cysteamine. Sci Rep. 2022 Apr 23;12(1):6668
PUBMED DOIClinical Relevance and Molecular Pathogenesis of the Emerging Serotypes 22F and 33F of Streptococcus pneumoniae in Spain
Sempere J, de Miguel S, González-Camacho F, Yuste J, Domenech M. Clinical Relevance and Molecular Pathogenesis of the Emerging Serotypes 22F and 33F of Streptococcus pneumoniae in Spain. Front Microbiol. 2020 Feb 27;11:309.
PUBMED DOICombination of Antibodies and Antibiotics as a Promising Strategy Against Multidrug-Resistant Pathogens of the Respiratory Tract
Domenech M, Sempere J, de Miguel S, Yuste J. Combination of Antibodies and Antibiotics as a Promising Strategy Against Multidrug-Resistant Pathogens of the Respiratory Tract. Front Immunol. 2018 Nov 20;9:2700. doi: 10.3389/fimmu.2018.02700. PMID: 30515172; PMCID: PMC6256034.
DOIChemotherapy with Phage Lysins Reduces Pneumococcal Colonization of the Respiratory Tract
Corsini B, Díez-Martínez R, Aguinagalde L, González-Camacho F, García-Fernández E, Letrado P, García P, Yuste J. Chemotherapy with Phage Lysins Reduces Pneumococcal Colonization of the Respiratory Tract. Antimicrob Agents Chemother. 2018 May 25;62(6):e02212-17. doi: 10.1128/AAC.02212-17. PMID: 29581113; PMCID: PMC5971604.
DOIImpact of Biological Therapies on the Immune Response after Pneumococcal Vaccination in Patients with Autoimmune Inflammatory Diseases
Richi P, Yuste J, Navío T, González-Hombrado L, Salido M, Thuissard-Vasallo I, Jiménez-Díaz A, Llorente J, Cebrián L, Lojo L, Steiner M, Cobo T, Martín MD, García-Castro M, Castro P, Muñoz-Fernández S. Impact of Biological Therapies on the Immune Response after Pneumococcal Vaccination in Patients with Autoimmune Inflammatory Diseases. Vaccines. 2021 Feb 28;9(3):203. doi: 10.3390/vaccines9030203. PMID: 33671007; PMCID: PMC7997274.
DOIPleiotropic Effects of Cell Wall Amidase LytA on Streptococcus pneumoniae Sensitivity to the Host Immune Response
Ramos-Sevillano E, Urzainqui A, Campuzano S, Moscoso M, González-Camacho F, Domenech M, Rodríguez de Córdoba S, Sánchez-Madrid F, Brown JS, García E, Yuste J. Pleiotropic effects of cell wall amidase LytA on Streptococcus pneumoniae sensitivity to the host immune response. Infect Immun. 2015 Feb;83(2):591-603. doi: 10.1128/IAI.02811-14. PMID: 25404032; PMCID: PMC4294232.
DOIPSGL-1 on Leukocytes is a Critical Component of the Host Immune Response against Invasive Pneumococcal Disease
Ramos-Sevillano E, Urzainqui A, de Andrés B, González-Tajuelo R, Domenech M, González-Camacho F, Sánchez-Madrid F, Brown JS, García E, Yuste J. PSGL-1 on Leukocytes is a Critical Component of the Host Immune Response against Invasive Pneumococcal Disease. PLoS Pathog. 2016 Mar 14;12(3):e1005500. doi: 10.1371/journal.ppat.1005500. PMID: 26975045; PMCID: PMC4790886.
DOIComparison of methods and characterization of small RNAs from plasma extracellular vesicles of HIV/HCV coinfected patients
Martínez-González E; Brochado-Kith O; Gómez-Sanz A; et al; Fernández-Rodríguez A (AC). (9/9). 2020. Small RNA sequencing from plasma extracellular vesicles of HIV/HCV coinfected patients: a protocol comparison SCIENTIFIC REPORTS. 9. ISSN 2045-2322.
DOIRelative telomere length impact on mortality of COVID-19: Sex differences
Virseda-Berdices A; Concostrina-Martinez L; Martínez-González O;et al; Fernández-Rodríguez A (AC). (14/14). 2022. Relative telomere length impact on mortality of COVID-19: Sex differences.Journal of medical virology. 95, pp.e28368. ISSN 0146-6615.
DOIHepatitis C Virus Influences HIV-1 Viral Splicing in Coinfected Patients
Martínez-Román P; López-Huertas MR; Crespo-Bermejo C; et al; Briz V (AC). (16/15). 2020. Hepatitis C virus influences HIV-1 viral splicing in coinfected patients JOURNAL OF CLINICAL MEDICINE. MDPI. ISSN 2077-0383.
DOIContent with Investigacion .
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Horacio Gil Gil
Research Scientist
ORCID code: 0000-0002-7114-6686
Degree in Veterinary Medicine in 1995 and PhD in Veterinary Medicine in 2002 from the University of Zaragoza. He did his PhD thesis at NEIKER Tecknalia (Derio, Vizcaya) and the National Center for Microbiology of Instituto de Salud Carlos III (CNM-ISCIII, Majadahonda, Madrid) on the biological cycle of Lyme disease in the Basque Country. After that, he developed his postdoctoral training in different aspects of the pathogenesis of tularemia at the Center for Infectious Diseases, Stony Brook University, New York (USA) for 3 years. In December 2005, he joined the Reference and Research Laboratory in Special Pathogens of the CNM-ISCIII where he developed diagnostic, reference and research activities, in Bartonella, Leptospira and pathogens of interest in bioterrorism. Between 2014-2016 he participated in the European Program for the Training of Microbiologists in Public Health (EUPHEM), organized by the European Centre for Disease Prevention and Control. During this program, he participated in an international mission for the investigation of a cholera outbreak in Ghana, proposed by the Bernhard Nocht Institute for Tropical Diseases in Hamburg (Germany). In December 2016, he worked as a laboratory consultant for the World Health Organization at their office in Phnom Penh (Cambodia). Subsequently, he worked one year with Médecins Sans Frontières as director and quality manager of the TB laboratory in Nukus (Uzbekistan).
In 2019, he joined the HIV Variability and Biology Unit at CNM-ISCIII, where he developed different reference and research activities, including his contribution to the molecular epidemiological surveillance of HIV-1 in Spain and the study of HIV-1 antiretroviral resistance. Since September 2022 he has been leading the Human Papillomavirus Unit at the CNM-ISCIII. -
Alicia Inés García Señán
Predoctoral Student UNED
Degree in Pharmacy in 2013 from the Complutense University of Madrid. She completed specialized health training in Microbiology and Parasitology at the Complejo Asistencial Universitario de Salamanca (2014-2018). During this period he studied a master's degree in Tropical Diseases at the University of Salamanca (2016). She has developed her professional activity as a clinical microbiologist at the Hospital de Santa Bárbara (Soria) (2018), Hospital Universitario Vall d'Hebrón (Barcelona) (2019-2022), and Hospital Central de la Defensa (Gómez Ulla) C.S.V.E, since 2022. In September 2024 she has started PhD studies at the Human Papillomavirus Unit of the CNM-ISCIII.
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Manuela Rodríguez Vargas
Técnico de Laboratorio
List of staff
Additional Information
Our group is interested in infections caused by the 8 known human herpes, which are very important etiological agents due to the high rates of infection, as well as their morbidity and mortality, especially in situations in which the immune system is immature (pediatric disease), senescent (pathologies in advanced age) or immunocompromised (transplanted).
They form a very heterogeneous group, but once the infection occurs, it persists for life through its latency phases. The pathogenicity of alpha- and beta-herpesviruses is related to primary infection and its recurrences, but in gamma-herpesviruses their main pathogenicity lies in their ability to produce tumors.
The main objective of the group is to respond to the medical problems caused by these infections from a multidisciplinary point of view, which includes virological, immunological and molecular aspects.
At present, the group's specific research objectives focus mainly on two topics:
Pathogenicity markers in congenital cytomegalovirus disease that modulate the immune system during infection and
Molecular characterization of the varicella zoster virus in cases of vaccine failure. The group's IP is part as a promoter partner of Spin-off: Virnóstica-ISCIII
Our group is interested in infections caused by the 8 known human herpes, which are very important etiological agents due to the high rates of infection, as well as their morbidity and mortality, especially in situations in which the immune system is immature (pediatric disease), senescent (pathologies in advanced age) or immunocompromised (transplanted).
They form a very heterogeneous group, but once the infection occurs, it persists for life through its latency phases. The pathogenicity of alpha- and beta-herpesviruses is related to primary infection and its recurrences, but in gamma-herpesviruses their main pathogenicity lies in their ability to produce tumors.
The main objective of the group is to respond to the medical problems caused by these infections from a multidisciplinary point of view, which includes virological, immunological and molecular aspects.
At present, the group's specific research objectives focus mainly on two topics:
Pathogenicity markers in congenital cytomegalovirus disease that modulate the immune system during infection and
Molecular characterization of the varicella zoster virus in cases of vaccine failure. The group's IP is part as a promoter partner of Spin-off: Virnóstica-ISCIII