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Provirus reactivation is impaired in HIV-1 infected individuals on treatment with dasatinib and antiretroviral therapy.
Provirus reactivation is impaired in HIV-1 infected individuals on treatment with dasatinib and antiretroviral therapy. Vigón L, Martínez-Román P, Rodríguez-Mora S, Torres M, Puertas MC, Mateos E, Salgado M, Navarro A, Sánchez-Conde M, Ambrosioni J, Cervero M, Wyen C, Hoffmann C, Miró JM, Alcamí J, Podzamczer D, García-Gutiérrez V, Martínez-Picado J, Briz V, Rosa López-Huertas M, Planelles V, Coiras M (AC). Biochem Pharmacol. 2021 Oct;192:114666. doi: 10.1016/j.bcp.2021.114666. PMID: 34186065.
PUBMED DOIT-Cell-Specific Loss of the PI-3-Kinase p110α Catalytic Subunit Results in Enhanced Cytokine Production and Antitumor Response.
1. Aragoneses-Fenoll L, Ojeda G, Montes-Casado M, Acosta-Ampudia Y, Dianzani U, Portolés P, Rojo JM. T-Cell-Specific Loss of the PI-3-Kinase p110α Catalytic Subunit Results in Enhanced Cytokine Production and Antitumor Response. Front. Immunol. 2018 Feb 27;9:332.
PUBMED DOIETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis.
2. Aragoneses-Fenoll L, Montes-CasadoM, Ojeda G, Acosta YY, Herranz J, Martínez S, Blanco-Aparicio C, Criado G, Pastor J, Dianzani U, Portolés P, Rojo JM. ETP-46321, a dual p110α/δ class IA phosphoinositide 3-kinase inhibitor modulates T lymphocyte activation and collagen-induced arthritis. Biochem. Pharmacol. 2016 Apr 15;106:56-69. Epub 2016 Feb 13.
PUBMED DOISuppression of CD4+ T lymphocyte activation in vitro and experimental encephalomyelitis in vivo by the phosphatidyl inositol 3-kinase inhibitor PIK-75.
3. Acosta YY, Montes-Casado M, Aragoneses-Fenoll L, Dianzani U, Portoles P, Rojo JM. Suppression of CD4+ T lymphocyte activation in vitro and experimental encephalomyelitis in vivo by the phosphatidyl inositol 3-kinase inhibitor PIK-75. Int. J. Immunopathol. Pharmacol. 2014 Jan-Mar;27(1):53-67.
PUBMED DOIEffects of 3D nanocomposite bioceramic scaffolds on the immune response
4. Cicuendez M., Portolés P., Montes-Casado M., Izquierdo-Barba I., Vallet-Regı M., and Portolés M.T. Effects of 3D nanocomposite bioceramic scaffolds on the immune response. J. Mater. Chem. B, 2014, 2 (22), 3469-3479.
DOICharacteristics of TCR/CD3 complex CD3 chains of regulatory CD4+ T (Treg) lymphocytes: Role in Treg differentiation in vitro and impact on Treg in vivo.
5. Rojo, J. M., G. Ojeda, Y. Y. Acosta, M. Montes-Casado, G. Criado, and P. Portoles. Characteristics of TCR/CD3 complex CD3 chains of regulatory CD4+ T (Treg) lymphocytes: Role in Treg differentiation in vitro and impact on Treg in vivo. J. Leukoc. Biol. 2014, 95 (3): 441-450.
PUBMED DOIDissociation of actin polymerization and lipid raft accumulation by ligation of the Inducible Costimulator (ICOS, CD278)
6. Y. Acosta, G. Ojeda, M. P. Zafra, I. Seren-Bernardone, A. Sánchez, U. Dianzani, P. Portolés y J. M. Rojo. Dissociation of actin polymerization and lipid raft accumulation by ligation of the Inducible Costimulator (ICOS, CD278). Inmunología, 2012, 31 (1): 4-12.
DOIComplement regulatory protein Crry/p65 costimulation expands natural Treg cells with enhanced suppressive properties in proteoglycan-induced arthritis.
7. Ojeda G., Pini E., Eguiluz C., Montes-Casado M., Broere F., van Eden W., Rojo J.M., and Portolés P. Complement regulatory protein Crry/p65 costimulation expands natural Treg cells with enhanced suppressive properties in proteoglycan-induced arthritis. Arthritis Rheum. 2011 Jun;63(6):1562-72.
PUBMED DOIAdditional Information
This group constitutes the National Poliovirus Laboratory (Polio Eradication Plan), integrated into the European network WHO/EURO Polio Laboratory Network and coordinating, in turn, the National Network of Laboratories for the study of paralysis cases in Research on enterovirus and parechovirus infections in the pediatric population has been funded since 2013 through research projects (PI PI12/00904; PI15CIII/00020; PI18CIII/00017), of which María Cabrerizo is PI and in which epidemiologists (CNE) and pediatricians and microbiologists from more than 20 SNS hospitals participate.
The PI belongs to the consolidated research group RITIP-IdiPaz and CIBERESP. Since 1999, the group has been carrying out the virological study of environmental samples (wastewater and treated water) from the CAM, through a contract with the CYII. Finally, the group is responsible for the diagnosis and characterization of gastrointestinal infections caused by viruses (norovirus, rotavirus and others) and for the investigation of outbreaks (CS of the CNM).
This group constitutes the National Poliovirus Laboratory (Polio Eradication Plan), integrated into the European network WHO/EURO Polio Laboratory Network and coordinating, in turn, the National Network of Laboratories for the study of paralysis cases in Research on enterovirus and parechovirus infections in the pediatric population has been funded since 2013 through research projects (PI PI12/00904; PI15CIII/00020; PI18CIII/00017), of which María Cabrerizo is PI and in which epidemiologists (CNE) and pediatricians and microbiologists from more than 20 SNS hospitals participate.
The PI belongs to the consolidated research group RITIP-IdiPaz and CIBERESP. Since 1999, the group has been carrying out the virological study of environmental samples (wastewater and treated water) from the CAM, through a contract with the CYII. Finally, the group is responsible for the diagnosis and characterization of gastrointestinal infections caused by viruses (norovirus, rotavirus and others) and for the investigation of outbreaks (CS of the CNM).