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Investigación
Viral Infection and Immunity
Publicaciones destacadas
Where are we with monoclonal antibodies for multidrug-resistant infections?
Where are we with monoclonal antibodies for multidrug-resistant infections? McConnell MJ. Drug Discov Today. 2019 May;24(5):1132-1138. doi: 10.1016/j.drudis.2019.03.002.
PUBMEDPeptidoglycan recycling contributes to intrinsic resistance to fosfomycin in Acinetobacter baumannii
Peptidoglycan recycling contributes to intrinsic resistance to fosfomycin in Acinetobacter baumannii. Gil-Marqués ML, Moreno-Martínez P, Costas C, Pachón J, Blázquez J, McConnell MJ. J Antimicrob Chemother. 2018 Nov 1;73(11):2960-2968. doi: 10.1093/jac/dky289.
PUBMEDImmunization with lipopolysaccharide-free outer membrane complexes protects against Acinetobacter baumannii infection
Immunization with lipopolysaccharide-free outer membrane complexes protects against Acinetobacter baumannii infection. Pulido MR, García-Quintanilla M, Pachón J, McConnell MJ. Vaccine. 2018 Jul 5;36(29):4153-4156. doi: 10.1016/j.vaccine.2018.05.113.
PUBMEDPhenotypic changes associated with Colistin resistance due to Lipopolysaccharide loss in Acinetobacter baumannii
Phenotypic changes associated with Colistin resistance due to Lipopolysaccharide loss in Acinetobacter baumannii. Carretero-Ledesma M, García-Quintanilla M, Martín-Peña R, Pulido MR, Pachón J, McConnell MJ. Virulence. 2018 Dec 31;9(1):930-942. doi: 10.1080/21505594.2018.1460187.
PUBMEDCurso de Gestión de Calidad y Buenas Prácticas de Laboratorio. Ed. 3
Grammatico JP, Cuevas L (Edits.) y Grupo de expertos de la Organización Panamericana de la Salud OPS/OMS. Curso de Gestión de Calidad y Buenas Prácticas de Laboratorio. Ed. 3. OPS/OMS;. Washington, D.C., 2016. Disponible en: “http://iris.paho.org/xmlui/handle/123456789/31168”. ISBN: 978-92-75-11906-8
Gestión de la Calidad para laboratorios de ensayo. 1ª ed.
Grammatico JP, Cuevas L (Edits.). Gestión de la Calidad para laboratorios de ensayo. 1ª ed. Conicet-Madri+d; Buenos Aires, 2011. Disponible en: “http://www.madrimasd.org/Laboratorios/Documentos/Red-Laboratorios/documentos/Gest_Calidad_Ensayo.pdf”. ISBN: 978-950-692-095-1
Curso de Gestión de Calidad y Buenas Prácticas de Laboratorio.
Grupo de expertos de la Organización Panamericana de la Salud OPS/OMS. Curso de Gestión de Calidad y Buenas Prácticas de Laboratorio. OPS; Documentos Técnicos THR/HT 2009/001. Washington, D.C., 2009. ISBN: 978-92-75-32977-1
Guía Latinoamericana para la implementación de Código de Ética en los laboratorios de salud.
Grupo de expertos de la Organización Panamericana de la Salud (OPS/OMS). Guía Latinoamericana para la implementación de Código de Ética en los laboratorios de salud. Organización Panamericana de la Salud. Documentos Técnicos. Políticas y Regulación. THS/EV-2007/001; 2007. ISBN: 92-7-532702-5
Identification of HIV-1 circulating BF1 recombinant form (CRF75_BF1) of Brazilian origin that also circulates in Southwestern Europe
Bacqué J, Delgado E, Gil H, Ibarra S, Benito S, García-Arata I, Moreno-Lorenzo M, Sáez de Arana E, Gómez-González C, Sánchez M, Montero V and Thomson MM. Front Microbiol. 2023. 14: 1301374
PUBMED DOIFactors associated with HIV-1 resistance to integrase strand transfer inhibitors in Spain: Implications for dolutegravir-containing regimens.
Gil H, Delgado E, Benito S, Moreno-Lorenzo M, Thomson MM and Spanish Group for the study of antirretroviral drug Resistance. Front Microbiol. 2022. 13:1051096
PUBMED DOITransmission clusters, predominantly associated with men who have sex with men, play a main role in the propagation of HIV-1 in Northern Spain (2013-2018).
Gil H, Delgado E, Benito S, Georgalis L, Montero V, Sánchez M, Cañada-García JE, García-Bodas E, Diaz A, Thomson MM and Spanish group of the study of new HIV diagnoses. Front Microbiol. 2022. 13:782609
PUBMED DOIHigh-Resolution Melting Assay to Detect the Mutations That Cause the Y132F and G458S Substitutions at the ERG11 Gene Involved in Azole Resistance in Candida parapsilosis
Nuria Trevijano-Contador, Elena López-Peralta, Jorge López-López, Alejandra Roldán, Cristina de Armentia, Óscar Zaragoza. Mycoses 2024 Nov;67(11):e13811
PUBMED DOIBroad Protection against Invasive Fungal Disease from a Nanobody Targeting the Active Site of Fungal β-1,3-Glucanosyltransferases
Redrado-Hernández S, Macías-León J, Castro-López J, Belén Sanz A, Dolader E, Arias M, González-Ramírez AM, Sánchez-Navarro D, Petryk Y, Farkaš V, Vincke C, Muyldermans S, García-Barbazán I, Del Agua C, Zaragoza O, Arroyo J, Pardo J, Gálvez EM, Hurtado-Guerrero R. Angew Chem Int Ed Engl. 2024 Aug 19;63(34):e202405823.
PUBMED DOIDiagnósitico microbiológico y control de la legionelosis
Pelaz Antolín, C., et al., En Procedimientos en Microbiología Clínica, E.C.y.R. Cantón, Editor. 2005, SEIMC. p. 1-72.
PUBMEDLegionella-Biofilms-Amebas, un problema industrial, de sanidad ambiental y de salud pública
Juana María González-Rubio, Celia Játiva, Almudena Cascajero, Fernando González-Camacho. Infoplagas, nº 112, agosto 2023 pags: 20-24. (Artículo de divulgación).
DOIPrograma de Legionelosis. En Echevarría Mayo JE y Oteo Iglesias J (Editores). Programas de Vigilancia Microbiológica pags: 74-80. Centro Nacional de Microbiología, Madrid: Instituto de Salud Carlos III, 2021.
Bellido B y Pelaez C: Programa de Legionelosis. En Echevarría Mayo JE y Oteo Iglesias J (Editores). Programas de Vigilancia Microbiológica pags: 74-80. Centro Nacional de Microbiología, Madrid: Instituto de Salud Carlos III, 2021.
Content with Investigacion .
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Mónica Valiente Novillo
Técnico de laboratorio. Convocatoria empleo juvenial (PEJ-2021-TL_BMD-21100)
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Noelia Castrillo Garrido
Técnico de Laboratorio. Contratada de Proyecto PID2021-127477OB-I00 (AEI)
ORCID code: 0000-0003-1676-9693
List of staff
Información adicional
The researchers of the Viral Infection and Immunity Unit (UIVI) are part of the CIBER de Infectious Diseases (CIBERINFEC) as an independent group (https://www.ciberinfec.es/grupos/grupo-de-investigacion?id=27501). The UIVI studies the immunopathology of clinically relevant infections in humans, such as chronic viral hepatitis (Hepatitis B, C and D), HIV, and SARS-CoV-2, and their impact on the clinical evolution of infected patients. We also analyse the evolution of the patient after controlling viral replication or after eliminating the virus spontaneously or by antiviral treatment.
The group focuses mainly on translational research in which collaborating clinical groups also participate. On the one hand, ‘omics’ techniques such as genomics, transcriptomics, proteomics, metabolomics, epigenetics and metagenomics are used, which, depending on the type of study, are targeted or not. On the other hand, specific laboratory assays designed in-house, such as PCR, RT-PCR, immunoassays for virus titration and neutralisation, production of monoclonal antibodies, among others, are carried out. With the molecular data obtained from patient samples, we perform bioinformatics/statistical analyses, analysing their association with the clinical condition of the patients and their subsequent evolution.