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HIV Biology and Variability

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Biología y Variabilidad del VIH

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Boldine-derived alkaloids inhibit the activity of DNA topoisomerase I and growth of Mycobacterium tuberculosis.

García MT, Carreño D, Tirado-Vélez JM, Ferrándiz MJ, Rodrigues L, Gracia B, Amblar M, Ainsa JA*, de la Campa AG. Front Microbiol. 9:493 (2018).

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Nrf2 plays a protective role against intravascular hemolysis-mediated acute kidney injury.

Rubio-Navarro A, Vázquez-Carballo C, Guerrero-Hue M, García-Caballero C, Herencia C, Gutierrez E, Yuste C, Sevillano A, Praga M, Egea J, Cannata P, Cortegano I, de Andrés B, Gaspar ML, Cadenas S, Michalska P, León R, Ortiz, A, Egido J, Moreno JA. Front Pharmacol. 2019; 10: 740.

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Multidrug-resistant gram-negative bacteria in Spanish ICU patients: clinical and microbiological characterization (MURAN-UCI Project).

9. Multidrug-resistant gram-negative bacteria in Spanish ICU patients: clinical and microbiological characterization (MURAN-UCI Project). Autores: Ramirez de Arellano E, López-Causapé C, Delgado-Valverde M, Arroyo Muñoz FJ, Alemparte-Pardavila E, Arca-Suárez J, Ayestarán I, Calvo Montes J, Cañada-Garcia J, Garcia-Cobos S, García-Fernández S, Gijón Cordero D, González-López JJ, Mir-Cros A, Nuvials X, Pérez-Vázquez M, Pomares-de la Peña A, Pampín-Garcia M, Riazzo C, Rodríguez-Gómez J, Rojo-Molinero E, Ruiz-Garbajosa P, Soriano C, Suberviola Cañas B, Taltavull B, Garnacho-Montero J, Oliver Palomo A, Oteo-Iglesias J; MURAN-UCI Spanish group. Revista: Microbiol Spectr. 2026 Feb 3;14(2):e0298725.

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Human immunodeficiency virus type 1 and related primate lentiviruses engage clathrin through Gag-Pol or Gag

Popov S, Strack B, Sanchez-Merino V, Popova E, Rosin H, Gottlinger HG; J Virol. 2011 Apr;85(8):3792-801

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An expanded agar base secreening method for azole resistant Aspergillus fumigatus

Lucio J, Gonzalez-Jimenez I, Garcia-Rubio R, Cuetara MS and Mellado E. Mycoses 2022, 65 (2): 178-185.

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Broth microdilution protocol for determining antimicrobial susceptibility of Legionella pneumophila to clinically relevant antimicrobials

Sewell M, Farley C, Portal EAR, Lindsay D, Ricci ML, Jarraud S, Scaturro M, Descours G, Krøvel AV, Barton R, Boostom I, Ure R, Kese D, Gaia V, Golob M, Paukner S, Ginevra C, Afshar B, Nadarajah S, Wybo I, Michel C, Echahdi F, González-Rubio JM, González-Camacho F, Mentasti M, Flountzi AS, Petzold M, Moran-Gilad J, Uldum S, Winchell J, Wooton M, Bernard K, Jones LC, Chalker VJ, Spiller OB. J Microbiol Methods. 2025 Jan;228:107071.

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Trends in invasive bacterial diseases during the first 2 years of the COVID-19 pandemic: analyses of prospective surveillance data from 30 countries and territories in the IRIS Consortium

Shaw D, Abad R, Amin-Chowdhury Z, Bautista A, Bennett D, Broughton K, Cao B, Casanova C, Choi EH, Chu YW, Claus H, Coelho J, Corcoran M, Cottrell S, Cunney R, Cuypers L, Dalby T, Davies H, de Gouveia L, Deghmane AE, Demczuk W, Desmet S, Domenech M, Drew R, du Plessis M, Duarte C, Erlendsdóttir H, Fry NK, Fuursted K, Hale T, Henares D, Henriques-Normark B, Hilty M, Hoffmann S, Humphreys H, Ip M, Jacobsson S, Johnson C, Johnston J, Jolley KA, Kawabata A, Kozakova J, Kristinsson KG, Krizova P, Kuch A, Ladhani S, Lâm TT, León ME, Lindholm L, Litt D, Maiden MCJ, Martin I, Martiny D, Mattheus W, McCarthy ND, Meehan M, Meiring S, Mölling P, Morfeldt E, Morgan J, Mulhall R, Muñoz-Almagro C, Murdoch D, Murphy J, Musilek M, Mzabi A, Novakova L, Oftadeh S, Perez-Argüello A, Pérez-Vázquez M, Perrin M, Perry M, Prevost B, Roberts M, Rokney A, Ron M, Sanabria OM, Scott KJ, Sheppard C, Siira L, Sintchenko V, Skoczyńska A, Sloan M, Slotved HC, Smith AJ, Steens A, Taha MK, Toropainen M, Tzanakaki G, Vainio A, van der Linden MPG, van Sorge NM, Varon E, Vohrnova S, von Gottberg A, Yuste J, Zanella R, Zhou F, Brueggemann AB. Lancet Digit Health. 2023 Sep;5(9):e582-e593.

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Paenibacillus spp. isolated from human and environmental samples in Spain: detection of 11 new species.

Sáez-Nieto JA, Medina-Pascual MJ, Carrasco G, Garrido N, Fernandez-Torres MA, Villalón P, Valdezate S. Paenibacillus spp. isolated from human and environmental samples in Spain: detection of 11 new species. New Microbes New Infect. 2017. 24;19:19-27.

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Información adicional

The activities of the HIV viral and biology unit (UBVVIH) include research, service to the National Health System (NHS) and the administration of Justice and teaching. Its main lines of research are molecular epidemiology and HIV-1 phylogeny, in which the UBVVIH has carried out numerous national and international collaborations, focusing on the identification of viral genetic forms and the study of their correlations with epidemiological variables. Related lines are phylodynamics and phylogeography, which study the origin and dynamics of growth and spread of HIV-1 variants. Such studies can be used to better understand the evolution of the epidemic and to plan public health actions. 

The UBVHIV also produces and characterises primary isolates and functional clones of the envelope of various genetic forms of HIV-1, which are deposited in repositories and used by numerous international groups. Other lines of research are described in the corresponding section. In terms of service to the NHS, the UBVVIH carries out antiretroviral resistance tests and prediction of tropism as a therapeutic guide in HIV-1 infected patients. As for its collaboration with the Justice Administration, the UBVVIH carries out expert opinions through phylogenetic studies of sequences for legal cases of possible HIV transmissions.

Content with Investigacion Biología y Variabilidad del VIH .