We protect your health through science
Investigación
HIV Biology and Variability
Publicaciones destacadas
Tarragó, D.; Mateos, M.-L.; Avellón, A.; Pérez-Vázquez, M.-D.; Tenorio, A.2004
Tarragó, D.; Mateos, M.-L.; Avellón, A.; Pérez-Vázquez, M.-D.; Tenorio, A.2004. Quantitation of Cytomegalovirus DNA in Cerebrospinal Fluid and Serum Specimens from AIDS Patients Using a Novel Highly Sensitive Nested Competitive PCR and the Cobas Amplicor CMV Monitor™ Journal of Medical Virology. 72-2, pp.249-256. ISSN 01466615. 10. Tarragó, D.; Quereda, C.; Tenorio, A.2003. Different cytomegalovirus glycoprotein B genotype distribution in serum and cerebrospinal fluid specimens determined by a novel multiplex nested PCR Journal of Clinical Microbiology. 41-7, pp.2872-2877. ISSN 00951137.
Fernandez-Garcia, Maria Dolores (AC); Kebe, Ousmane; Fall, Aichatou D.; Dia, Hamet; Diop, Ousmane M.; Delpeyroux, Francis; Ndiaye, Kader. 2016.
Fernandez-Garcia, Maria Dolores (AC); Kebe, Ousmane; Fall, Aichatou D.; Dia, Hamet; Diop, Ousmane M.; Delpeyroux, Francis; Ndiaye, Kader. (1/ 7). 2016. Enterovirus A71 Genogroups C and E in Children with Acute Flaccid Paralysis, West Africa EMERGING INFECTIOUS DISEASES. 22-4, pp.753-755. ISSN 1080-6040.
Molecular epidemiology of coxsackievirus B3 infection in Spain, 2004-2015.
K Calderón, M Díaz-de Cerio, C Muñoz-Almagro, N Rabella, I Martínez-Rienda, A Moreno-Docón, G Trallero, M Cabrerizo*. Molecular epidemiology of coxsackievirus B3 infection in Spain, 2004-2015. Arch Virol 161: 1365-1370 (2016).
PUBMED DOIDevelopment and Evaluation of a Serological Assay for the Diagnosis of Tuberculosis in Alpacas and Llamas.
Development and Evaluation of a Serological Assay for the Diagnosis of Tuberculosis in Alpacas and Llamas. Infantes-Lorenzo, Jose A.; Whitehead, Claire E.; Moreno, Inmaculada; et ál..FRONTIERS IN VETERINARY SCIENCE Volumen: 5 Número de artículo: 189 Fecha de publicación: AUG 13 2018
PUBMED DOIInfluence of the Microenvironment in the Transcriptome of Leishmania infantum Promastigotes: Sand Fly versus Culture
Influence of the Microenvironment in the Transcriptome of Leishmania infantum Promastigotes: Sand Fly versus Culture. Alcolea, Pedro J.; Alonso, Ana; Dominguez, Mercedes; et ál..PLOS NEGLECTED TROPICAL DISEASES Volumen: 10 Número: 5 Número de artículo: e0004693 Fecha de publicación: MAY 2016
PUBMED DOIFernandez-Garcia MD, Kebe O, Fall AD, Ndiaye K. Identification and molecular characterization of non-polio enteroviruses from children with acute flaccid paralysis in West Africa, 2013-2014.
Fernandez-Garcia MD, Kebe O, Fall AD, Ndiaye K. Identification and molecular characterization of non-polio enteroviruses from children with acute flaccid paralysis in West Africa, 2013-2014. Scientific Reports. 2017 Jun 19; 7(1):3808. doi: 10.1038/s41598-017-03835-1 ISSN 2045-2322 PMID 28630462
Fernandez-Garcia MD, Manasi Majumdar, Ousmane Kebe, Kader Ndiaye, Javier Martin. Identification and whole-genome characterization of a recombinant Enterovirus B69 isolated from a patient with Acute Flaccid Paralysis in Niger, 2015
Fernandez-Garcia MD, Manasi Majumdar, Ousmane Kebe, Kader Ndiaye, Javier Martin. Identification and whole-genome characterization of a recombinant Enterovirus B69 isolated from a patient with Acute Flaccid Paralysis in Niger, 2015. Scientific Reports. 2018 Feb; 8(1):2181. doi: 10.1038/s41598-018-20346-9. ISSN 2045-2322 PMID 29391547
Fernandez-Garcia MD, Majumdar M, Kebe O, Fall AD, Kone M, Kande M, Dabo M, Sylla MS, Sompare D, Howard W, Faye O, Martin J, Ndiaye K. Emergence of Vaccine- Derived Polioviruses during Ebola Virus Disease Outbreak, Guinea, 2014-2015.
Fernandez-Garcia MD, Majumdar M, Kebe O, Fall AD, Kone M, Kande M, Dabo M, Sylla MS, Sompare D, Howard W, Faye O, Martin J, Ndiaye K. Emergence of Vaccine- Derived Polioviruses during Ebola Virus Disease Outbreak, Guinea, 2014-2015. Emerg Infect Dis. 2018 Jan;24(1):65-74. doi: 10.3201/eid2401.171174. PMID: 29260690; PMCID: PMC5749474.
Cabrerizo M, García-Iñiguez JP, Munell F, Amado A, Madurga-Revilla P, Rodrigo C, Pérez S, Martínez-Sapiña A, Antón A, Suárez G, Rabella N, Del Campo V, Otero A, Masa-Calles J. First Cases of Severe Flaccid Paralysis Associated With Enterovirus D68 Infection in Spain, 2015-2016.
Cabrerizo M, García-Iñiguez JP, Munell F, Amado A, Madurga-Revilla P, Rodrigo C, Pérez S, Martínez-Sapiña A, Antón A, Suárez G, Rabella N, Del Campo V, Otero A, Masa-Calles J. First Cases of Severe Flaccid Paralysis Associated With Enterovirus D68 Infection in Spain, 2015-2016. Pediatr Infect Dis J. 2017 Dec;36(12):1214-1216. doi: 10.1097/INF.0000000000001668. PMID: 28661963.
van Beek J, de Graaf M, Al-Hello H, Allen DJ, Ambert-Balay K, Botteldoorn N, Brytting M, Buesa J, Cabrerizo M, Chan M, Cloak F, Di Bartolo I, Guix S, Hewitt J, Iritani N, Jin M, Johne R, Lederer I, Mans J, Martella V, Maunula L, McAllister G, Niendorf S, Niesters HG, Podkolzin AT, Poljsak-Prijatelj M, Rasmussen LD, Reuter G, Tuite G, Kroneman A, Vennema H, Koopmans MPG; NoroNet. Molecular surveillance of norovirus, 2005-16
van Beek J, de Graaf M, Al-Hello H, Allen DJ, Ambert-Balay K, Botteldoorn N, Brytting M, Buesa J, Cabrerizo M, Chan M, Cloak F, Di Bartolo I, Guix S, Hewitt J, Iritani N, Jin M, Johne R, Lederer I, Mans J, Martella V, Maunula L, McAllister G, Niendorf S, Niesters HG, Podkolzin AT, Poljsak-Prijatelj M, Rasmussen LD, Reuter G, Tuite G, Kroneman A, Vennema H, Koopmans MPG; NoroNet. Molecular surveillance of norovirus, 2005-16: an epidemiological analysis of data collected from the NoroNet network. Lancet Infect Dis. 2018 May;18(5):545-553. doi: 10.1016/S1473-3099(18)30059-8. Epub 2018 Jan 26. PMID: 29396001.
González-Serrano L, Muñoz-Algarra M, González-Sanz R, Portero-Azorín MF, Amaro MJ, Higueras P, Cabrerizo M. Viral gastroenteritis in hospitalized patients: Evaluation of immunochromatographic methods for rapid detection in stool samples. J Clin Virol. 2020 Jul;
González-Serrano L, Muñoz-Algarra M, González-Sanz R, Portero-Azorín MF, Amaro MJ, Higueras P, Cabrerizo M. Viral gastroenteritis in hospitalized patients: Evaluation of immunochromatographic methods for rapid detection in stool samples. J Clin Virol. 2020 Jul; 128:104420. doi: 10.1016/j.jcv.2020.104420. Epub 2020 May 15. PMID: 32454428.
Bubba L, Broberg EK, Jasir A, Simmonds P, Harvala H; Enterovirus study collaborators. Circulation of non-polio enteroviruses in 24 EU and EEA countries between 2015 and 2017
Bubba L, Broberg EK, Jasir A, Simmonds P, Harvala H; Enterovirus study collaborators. Circulation of non-polio enteroviruses in 24 EU and EEA countries between 2015 and 2017: a retrospective surveillance study. Lancet Infect Dis. 2020 Mar;20(3):350-361. doi: 10.1016/S1473-3099(19)30566-3. Epub 2019 Dec 20. PMID: 31870905.
Fernandez-Garcia MD, Simon-Loriere E, Kebe O, Sakuntabhai A, Ndiaye K. Identification and molecular characterization of the first complete genome sequence of Human Parechovirus type 15. Sci Rep. 2020 Apr 21
Fernandez-Garcia MD, Simon-Loriere E, Kebe O, Sakuntabhai A, Ndiaye K. Identification and molecular characterization of the first complete genome sequence of Human Parechovirus type 15. Sci Rep. 2020 Apr 21;10(1):6759. doi: 10.1038/s41598-020-63467-w. PMID: 32317760; PMCID: PMC7174385.
Casas-Alba D, Valero-Rello A, Muchart J, Armangué T, Jordan I, Cabrerizo M, Molero-Luís M, Artuch R, Fortuny C, Muñoz-Almagro C, Launes C. Cerebrospinal Fluid Neopterin in Children With Enterovirus-Related Brainstem Encephalitis. Pediatr Neurol. 2019 Jul
Casas-Alba D, Valero-Rello A, Muchart J, Armangué T, Jordan I, Cabrerizo M, Molero-Luís M, Artuch R, Fortuny C, Muñoz-Almagro C, Launes C. Cerebrospinal Fluid Neopterin in Children With Enterovirus-Related Brainstem Encephalitis. Pediatr Neurol. 2019 Jul; 96:70-73. doi: 10.1016/j.pediatrneurol.2019.01.024. Epub 2019 Feb 7. PMID: 30935719.
González-Sanz R, Taravillo I, Reina J, Navascués A, Moreno-Docón A, Aranzamendi M, Romero MP, Del Cuerpo M, Pérez-González C, Pérez-Castro S, Otero A, Cabrerizo M. Enterovirus D68-associated respiratory and neurological illness in Spain, 2014-2018.
González-Sanz R, Taravillo I, Reina J, Navascués A, Moreno-Docón A, Aranzamendi M, Romero MP, Del Cuerpo M, Pérez-González C, Pérez-Castro S, Otero A, Cabrerizo M. Enterovirus D68-associated respiratory and neurological illness in Spain, 2014-2018. Emerg Microbes Infect. 2019;8(1):1438-1444. doi: 10.1080/22221751.2019.1668243. PMID: 31571527; PMCID: PMC6781473.
Monocytic Myeloid-Derived Suppressor Cells Accumulate in Renal Transplant Patients and Mediate CD4(+) Foxp3(+) Treg Expansion
Luan Y, Mosheir E, Menon MC, Wilson D, Woytovich C, Ochando J, Murphy B. Monocytic Myeloid-Derived Suppressor Cells Accumulate in Renal Transplant Patients and Mediate CD4(+) Foxp3(+) Treg Expansion. 2013. Am J Transplant.13(12):3123-31.
PUBMED DOIRiquelme P, Haarer J, Kammler A, Walter L, Tomiuk S, Ahrens N, Goecze I, Wege A, Fändrich F, Schlitt H, Banas B, Lutz M, Sawitzki B, Ochando J, Geissler E and Hutchinson J. Generation of BTNL8+ TIGIT+ Tregs by Human Regulatory Macrophages Before Kidney Transplantation. Nat Commun.
Riquelme P, Haarer J, Kammler A, Walter L, Tomiuk S, Ahrens N, Goecze I, Wege A, Fändrich F, Schlitt H, Banas B, Lutz M, Sawitzki B, Ochando J, Geissler E and Hutchinson J. Generation of BTNL8+ TIGIT+ Tregs by Human Regulatory Macrophages Before Kidney Transplantation. Nat Commun. 2018; Jul 20;9(1):2858. PMID: 30030423.
Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance
Braza MS, Lameijer M, Sanchez-Gaytan B, Arts R, Pérez-Medina C, Conde P, Brahmachary M, van der Touw W, Fay F, Kluza E, Kossatz S, Stroes E, Kroon J, Dress R, Salem F, Rialdi A, Reiner T, Boros P, van Leent M, Strijkers G, Calcagno C, Ginhoux F, Marazzi I, Lutgens E, Nicolaes G, Weber C, Swirski F, Nahrendorf M, Fisher E, Fayad Z, Duivenvoorden R, Netea M, Mulder WJ, and Ochando J. Inhibiting Inflammation with Myeloid Cell-Specific Nanobiologics Promotes Organ Transplant Acceptance.Immunity. 2018; 20;49(5):819-828.e6. PMID: 30413362.
PUBMED DOIFernandez-Garcia MD, Volle R, Joffret ML, Sadeuh-Mba SA, Gouandjika-Vasilache I, Kebe O, Wiley MR, Majumdar M, Simon-Loriere E, Sakuntabhai A, Palacios G, Martin J, Delpeyroux F, Ndiaye K, Bessaud M. Genetic Characterization of Enterovirus A71 Circulating in Africa.
Fernandez-Garcia MD, Volle R, Joffret ML, Sadeuh-Mba SA, Gouandjika-Vasilache I, Kebe O, Wiley MR, Majumdar M, Simon-Loriere E, Sakuntabhai A, Palacios G, Martin J, Delpeyroux F, Ndiaye K, Bessaud M. Genetic Characterization of Enterovirus A71 Circulating in Africa. Emerg Infect Dis. 2018 Apr;24(4):754-757. doi: 10.3201/eid2404.171783. PMID: 29553325; PMCID: PMC5875259.
Información adicional
The activities of the HIV viral and biology unit (UBVVIH) include research, service to the National Health System (NHS) and the administration of Justice and teaching. Its main lines of research are molecular epidemiology and HIV-1 phylogeny, in which the UBVVIH has carried out numerous national and international collaborations, focusing on the identification of viral genetic forms and the study of their correlations with epidemiological variables. Related lines are phylodynamics and phylogeography, which study the origin and dynamics of growth and spread of HIV-1 variants. Such studies can be used to better understand the evolution of the epidemic and to plan public health actions.
The UBVHIV also produces and characterises primary isolates and functional clones of the envelope of various genetic forms of HIV-1, which are deposited in repositories and used by numerous international groups. Other lines of research are described in the corresponding section. In terms of service to the NHS, the UBVVIH carries out antiretroviral resistance tests and prediction of tropism as a therapeutic guide in HIV-1 infected patients. As for its collaboration with the Justice Administration, the UBVVIH carries out expert opinions through phylogenetic studies of sequences for legal cases of possible HIV transmissions.