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Investigation
Respiratory viruses and Influenza
Research Lines
Content with Investigacion .
Virus Respiratorios y Gripe
• Gripe humana y animal. Vigilancia de su circulación. Antigripales, resistencias virales. Vacunas
• Infecciones víricas respiratorias en pacientes pediátricos • Diagnóstico, referencia y Nuevos procedimientos basados en la metagenómica viral para el estudio de virus respiratorios.
• Epidemiologia de Virus respiratorios: Gripe, Virus Respiratorio Sincitial, Adenovirus, Metapneumovirus humano, Coronavirus (MERS, 229E, OC43, HKU1, NL63), Parainfluenzavirus, Rinovirus, Bocavirus humano
• Virus respiratorios emergentes • Biodefensa y virus
Research projects
Content with Investigacion .
CURRENT PROJECTS: Award of the RETOS-COLABORATION 2019 Call for Proposals: Development of diagnostic kits using real-time multiplex PCR in liquid and gel format for the detection of viral diseases and sepsis.
Reference: RTC2019-007023-1 / MPY 292/20. Project funded by the Ministry of Science and Innovation and the State Research Agency.
PI: Inmaculada Casas and Giovanni Fedele.
Execution dates: 2020-2023.
Amount financed: 442,653 €.
Collaborator: Francisco Pozo
Publications
Lorente, E., A. Barriga, E. Barnea, C. Palomo, J. Garcia-Arriaza, C. Mir, M. Esteban, A. Admon, and D. López. 2019. Immunoproteomic analysis of a Chikungunya poxvirus-based vaccine reveals high HLA class II immunoprevalence. PLoS.Negl.Trop.Dis. 13:e0007547.
Lorente, E., A. Barriga, E. Barnea, C. Palomo, J. Garcia-Arriaza, C. Mir, M. Esteban, A. Admon, and D. López. 2019. Immunoproteomic analysis of a Chikungunya poxvirus-based vaccine reveals high HLA class II immunoprevalence. PLoS.Negl.Trop.Dis. 13:e0007547.
PUBMED DOILópez, D., A. Barriga, E. Lorente, and C. Mir. 2019. Immunoproteomic Lessons for Human Respiratory Syncytial Virus Vaccine Design. J.Clin.Med. 8.
López, D., A. Barriga, E. Lorente, and C. Mir. 2019. Immunoproteomic Lessons for Human Respiratory Syncytial Virus Vaccine Design. J.Clin.Med. 8.
PUBMED DOIBrait, V. H., F. Miro-Mur, I. Perez-de-Puig, L. Notario, B. Hurtado, J. Pedragosa, M. Gallizioli, F. Jimenez-Altayo, M. Arbaizar-Rovirosa, A. Otxoa-de-Amezaga, J. Monteagudo, M. Ferrer-Ferrer, l. R. de, X, E. Bonfill-Teixidor, A. Salas-Perdomo, A. Hernandez-Vidal, P. Garcia-de-Frutos, P. Lauzurica, and A. M. Planas. 2019. CD69 Plays a Beneficial Role in Ischemic Stroke by Dampening Endothelial Activation. Circ.Res. 124:279-291.
Brait, V. H., F. Miro-Mur, I. Perez-de-Puig, L. Notario, B. Hurtado, J. Pedragosa, M. Gallizioli, F. Jimenez-Altayo, M. Arbaizar-Rovirosa, A. Otxoa-de-Amezaga, J. Monteagudo, M. Ferrer-Ferrer, l. R. de, X, E. Bonfill-Teixidor, A. Salas-Perdomo, A. Hernandez-Vidal, P. Garcia-de-Frutos, P. Lauzurica, and A. M. Planas. 2019. CD69 Plays a Beneficial Role in Ischemic Stroke by Dampening Endothelial Activation. Circ.Res. 124:279-291.
DOILorente, E., J. Redondo-Anton, A. Martín-Esteban, P. Guasp, E. Barnea, P. Lauzurica, A. Admon, and J. A. López de Castro. 2019. Substantial Influence of ERAP2 on the HLA-B*40:02 Peptidome: Implications for HLA-B*27-Negative Ankylosing Spondylitis. Mol.Cell Proteomics. 18:2298-2309.
Lorente, E., J. Redondo-Anton, A. Martín-Esteban, P. Guasp, E. Barnea, P. Lauzurica, A. Admon, and J. A. López de Castro. 2019. Substantial Influence of ERAP2 on the HLA-B*40:02 Peptidome: Implications for HLA-B*27-Negative Ankylosing Spondylitis. Mol.Cell Proteomics. 18:2298-2309.
PUBMED DOILorente, E., C. Palomo, E. Barnea, C. Mir, V. M. Del, A. Admon, and D. López. 2019a. Natural Spleen Cell Ligandome in Transporter Antigen Processing-Deficient Mice. J.Proteome.Res. 18:3512-3520.
Lorente, E., C. Palomo, E. Barnea, C. Mir, V. M. Del, A. Admon, and D. López. 2019a. Natural Spleen Cell Ligandome in Transporter Antigen Processing-Deficient Mice. J.Proteome.Res. 18:3512-3520.
PUBMEDLorente, E., M. G. Fontela, E. Barnea, A. J. Martín-Galiano, C. Mir, B. Galocha, A. Admon, P. Lauzurica, and D. López. 2020. Modulation of Natural HLA-B*27:05 Ligandome by Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 2 (ERAP2). Mol.Cell Proteomics. 19:994-1004.
Lorente, E., M. G. Fontela, E. Barnea, A. J. Martín-Galiano, C. Mir, B. Galocha, A. Admon, P. Lauzurica, and D. López. 2020. Modulation of Natural HLA-B*27:05 Ligandome by Ankylosing Spondylitis-associated Endoplasmic Reticulum Aminopeptidase 2 (ERAP2). Mol.Cell Proteomics. 19:994-1004.
PUBMED DOIRedondo-Anton, J., M. G. Fontela, L. Notario, R. Torres-Ruiz, S. Rodriguez-Perales, E. Lorente, and P. Lauzurica. 2020. Functional Characterization of a Dual Enhancer/Promoter Regulatory Element Leading Human CD69 Expression. Front Genet. 11:552949.
Redondo-Anton, J., M. G. Fontela, L. Notario, R. Torres-Ruiz, S. Rodriguez-Perales, E. Lorente, and P. Lauzurica. 2020. Functional Characterization of a Dual Enhancer/Promoter Regulatory Element Leading Human CD69 Expression. Front Genet. 11:552949.
PUBMED DOIFontela, M. G., L. Notario, E. Alari-Pahissa, E. Lorente, and P. Lauzurica. 2019
Fontela, M. G., L. Notario, E. Alari-Pahissa, E. Lorente, and P. Lauzurica. 2019. The Conserved Non-Coding Sequence 2 (CNS2) Enhances CD69 Transcription through Cooperation between the Transcription Factors Oct1 and RUNX1. Genes (Basel) 10.
PUBMED DOIContent with Investigacion .
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Francisco Pozo
Científico Titular de OPIs
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Inmaculada Casas
Jefe de Grupo. Científico Titular de OPIs
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Mónica González-Esguevillas
Colaborador I+D+I de OPIs
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Mar Molinero Calamita
Colaborador I+D+I de OPIs
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María de la Montaña Iglesias Caballero
Contratado Predoctoral PFIS
List of staff
Additional Information
The Respiratory Viruses and Influenza Unit is the oldest WHO Influenza Center in our country (1968), designated as the National Influenza Center by the Ministry of Health in 1971, and is the national coordinator of the CCAA laboratories in the National Influenza Surveillance Network of the Influenza Surveillance System in Spain.
Its general objective is virological surveillance, detection and control of influenza in Spain. Since 1992, together with the Pediatric Service of the Severo Ochoa Hospital, a line of research has been developed based on the etiological study of viral respiratory infections in hospitalized children.
Since 2015, the La Paz Children's University Hospital and the Immunology Laboratory of the IIS-Fundación Jiménez Díaz have also participated, expanding the study to newborns and neonatal units.
To comprehensively study respiratory viruses and the response of the immune system in viral respiratory infections that affect newborns and pediatric patients.
Deepen the knowledge of the biological properties of the viruses involved in the disease: dependency/facilitation, balance between viruses and their adaptation in multiple infections, relationship with severity, existence of virome imbalance.
The Respiratory Viruses and Influenza Unit is the oldest WHO Influenza Center in our country (1968), designated as the National Influenza Center by the Ministry of Health in 1971, and is the national coordinator of the CCAA laboratories in the National Influenza Surveillance Network of the Influenza Surveillance System in Spain.
Its general objective is virological surveillance, detection and control of influenza in Spain. Since 1992, together with the Pediatric Service of the Severo Ochoa Hospital, a line of research has been developed based on the etiological study of viral respiratory infections in hospitalized children.
Since 2015, the La Paz Children's University Hospital and the Immunology Laboratory of the IIS-Fundación Jiménez Díaz have also participated, expanding the study to newborns and neonatal units.
To comprehensively study respiratory viruses and the response of the immune system in viral respiratory infections that affect newborns and pediatric patients.
Deepen the knowledge of the biological properties of the viruses involved in the disease: dependency/facilitation, balance between viruses and their adaptation in multiple infections, relationship with severity, existence of virome imbalance.