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Investigación
Respiratory viruses and Influenza
Líneas de investigación
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Virus Respiratorios y Gripe
• Gripe humana y animal. Vigilancia de su circulación. Antigripales, resistencias virales. Vacunas
• Infecciones víricas respiratorias en pacientes pediátricos • Diagnóstico, referencia y Nuevos procedimientos basados en la metagenómica viral para el estudio de virus respiratorios.
• Epidemiologia de Virus respiratorios: Gripe, Virus Respiratorio Sincitial, Adenovirus, Metapneumovirus humano, Coronavirus (MERS, 229E, OC43, HKU1, NL63), Parainfluenzavirus, Rinovirus, Bocavirus humano
• Virus respiratorios emergentes • Biodefensa y virus
Proyectos de investigación
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CURRENT PROJECTS: Award of the RETOS-COLABORATION 2019 Call for Proposals: Development of diagnostic kits using real-time multiplex PCR in liquid and gel format for the detection of viral diseases and sepsis.
Reference: RTC2019-007023-1 / MPY 292/20. Project funded by the Ministry of Science and Innovation and the State Research Agency.
PI: Inmaculada Casas and Giovanni Fedele.
Execution dates: 2020-2023.
Amount financed: 442,653 €.
Collaborator: Francisco Pozo
Publicaciones destacadas
Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals
2. Trevijano-Contador N, de Oliveira HC, García-Rodas R, Rossi SA, Llorente I, Zaballos Á, Janbon G, Ariño J, Zaragoza Ó. Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals. PLoS Pathog. 2018 May 18;14(5):e1007007.
PUBMED DOIReclassification of the Candida haemulonii complex as Candida haemulonii (C. haemulonii group I), C. duobushaemulonii sp. nov. (C. haemulonii group II), and C. haemulonii var. vulnera var. nov.: three multiresistant human pathogenic yeasts
4. Cendejas-Bueno E, Kolecka A, Alastruey-Izquierdo A, Theelen B, Groenewald M, Kostrzewa M, Cuenca-Estrella M, Gómez-López A, Boekhout T. Reclassification of the Candida haemulonii complex as Candida haemulonii (C. haemulonii group I), C. duobushaemulonii sp. nov. (C. haemulonii group II), and C. haemulonii var. vulnera var. nov.: three multiresistant human pathogenic yeasts. J Clin Microbiol.
PUBMED DOIMolecular Identification and Susceptibility Testing of Molds Isolated in a Prospective Surveillance of Triazole Resistance in Spain (FILPOP2 Study).
5. Alastruey-Izquierdo A, Alcazar-Fuoli L, Rivero-Menéndez O, Ayats J, Castro C, García-Rodríguez J, Goterris-Bonet L, Ibáñez-Martínez E, Linares-Sicilia MJ, Martin-Gomez MT, Martín-Mazuelos E, Pelaez T, Peman J, Rezusta A, Rojo S, Tejero R, Anza DV, Viñuelas J, Zapico MS, Cuenca-Estrella M; the FILPOP2 Project from GEMICOMED (SEIMC) and REIPI. Molecular Identification and Susceptibility Testing of Molds Isolated in a Prospective Surveillance of Triazole Resistance in Spain (FILPOP2 Study). Antimicrob Agents Chemother. 2018 Aug 27;62(9).
PUBMED DOIEvaluation of Bronchoalveolar Lavage Fluid Cytokines as Biomarkers for Invasive Pulmonary Aspergillosis in At-Risk Patients
6. Gonçalves SM, Lagrou K, Rodrigues CS, Campos CF, Bernal-Martínez L, Rodrigues F, Silvestre R, Alcazar-Fuoli L, Maertens JA, Cunha C, Carvalho A. Evaluation of Bronchoalveolar Lavage Fluid Cytokines as Biomarkers for Invasive Pulmonary Aspergillosis in At-Risk Patients. Front Microbiol. 2017 Nov 29;8:2362.
PUBMED DOIPolymorphisms in Host Immunity-Modulating Genes and Risk of Invasive Aspergillosis: Results from the AspBIOmics Consortium
7. Lupiañez CB, Canet LM, Carvalho A, Alcazar-Fuoli L, Springer J, Lackner M, Segura-Catena J, Comino A, Olmedo C, Ríos R, Fernández-Montoya A, Cuenca-Estrella M, Solano C, López-Nevot MÁ, Cunha C, Oliveira-Coelho A, Villaescusa T, Fianchi L, Aguado JM, Pagano L, López-Fernández E, Potenza L, Luppi M, Lass-Flörl C, Loeffler J, Einsele H, Vazquez L; PCRAGA Study Group, Jurado M, Sainz J. Polymorphisms in Host Immunity-Modulating Genes and Risk of Invasive Aspergillosis: Results from the AspBIOmics Consortium. Infect Immun. 2015 Dec 14;84(3):643-57.
PUBMED DOICell Wall Changes in Amphotericin B-Resistant Strains from Candida tropicalis and Relationship with the Immune Responses Elicited by the Host.
9. Mesa-Arango AC, Rueda C, Román E, Quintin J, Terrón MC, Luque D, Netea MG, Pla J and Zaragoza O. Cell Wall Changes in Amphotericin B-Resistant Strains from Candida tropicalis and Relationship with the Immune Responses Elicited by the Host. Antimicrob. Agents Chemother. 2016. 60(4):2326-35.
PUBMED DOIThe role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy
Benavides-Nieto M, Méndez-Echevarría A, Del Rosal T, García-García ML, Casas I, Pozo F, de la Serna O, Lopez-Granados E, Rodriguez-Pena R, Calvo C. The role of respiratory viruses in children with humoral immunodeficiency on immunoglobulin replacement therapy. Pediatr Pulmonol. 2019 Feb;54(2):194-199. Indice Impacto: 3,157. Revista en Q1.
PUBMED DOISeasonality and geographical spread of respiratory syncytial virus epidemics in 15 European countries, 2010 to 2016.
Broberg EK, Waris M, Johansen K, Snacken R, Penttinen P; European Influenza Surveillance Network. Seasonality and geographical spread of respiratory syncytial virus epidemics in 15 European countries, 2010 to 2016. Euro Surveill. 2018 Feb;23(5). Indice Impacto: 5,983. Revista en Decil 1
PUBMED DOIContent with Investigacion .
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Inmaculada Casas
Jefe de Grupo. Científico Titular de OPIs
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Francisco Pozo
Científico Titular de OPIs
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Mónica González-Esguevillas
Colaborador I+D+I de OPIs
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Mar Molinero Calamita
Colaborador I+D+I de OPIs
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María de la Montaña Iglesias Caballero
Contratado Predoctoral PFIS
List of staff
Información adicional
The Respiratory Viruses and Influenza Unit is the oldest WHO Influenza Center in our country (1968), designated as the National Influenza Center by the Ministry of Health in 1971, and is the national coordinator of the CCAA laboratories in the National Influenza Surveillance Network of the Influenza Surveillance System in Spain.
Its general objective is virological surveillance, detection and control of influenza in Spain. Since 1992, together with the Pediatric Service of the Severo Ochoa Hospital, a line of research has been developed based on the etiological study of viral respiratory infections in hospitalized children.
Since 2015, the La Paz Children's University Hospital and the Immunology Laboratory of the IIS-Fundación Jiménez Díaz have also participated, expanding the study to newborns and neonatal units.
To comprehensively study respiratory viruses and the response of the immune system in viral respiratory infections that affect newborns and pediatric patients.
Deepen the knowledge of the biological properties of the viruses involved in the disease: dependency/facilitation, balance between viruses and their adaptation in multiple infections, relationship with severity, existence of virome imbalance.
The Respiratory Viruses and Influenza Unit is the oldest WHO Influenza Center in our country (1968), designated as the National Influenza Center by the Ministry of Health in 1971, and is the national coordinator of the CCAA laboratories in the National Influenza Surveillance Network of the Influenza Surveillance System in Spain.
Its general objective is virological surveillance, detection and control of influenza in Spain. Since 1992, together with the Pediatric Service of the Severo Ochoa Hospital, a line of research has been developed based on the etiological study of viral respiratory infections in hospitalized children.
Since 2015, the La Paz Children's University Hospital and the Immunology Laboratory of the IIS-Fundación Jiménez Díaz have also participated, expanding the study to newborns and neonatal units.
To comprehensively study respiratory viruses and the response of the immune system in viral respiratory infections that affect newborns and pediatric patients.
Deepen the knowledge of the biological properties of the viruses involved in the disease: dependency/facilitation, balance between viruses and their adaptation in multiple infections, relationship with severity, existence of virome imbalance.