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Investigation
Respiratory viruses and Influenza
Research Lines
Content with Investigacion .
Virus Respiratorios y Gripe
• Gripe humana y animal. Vigilancia de su circulación. Antigripales, resistencias virales. Vacunas
• Infecciones víricas respiratorias en pacientes pediátricos • Diagnóstico, referencia y Nuevos procedimientos basados en la metagenómica viral para el estudio de virus respiratorios.
• Epidemiologia de Virus respiratorios: Gripe, Virus Respiratorio Sincitial, Adenovirus, Metapneumovirus humano, Coronavirus (MERS, 229E, OC43, HKU1, NL63), Parainfluenzavirus, Rinovirus, Bocavirus humano
• Virus respiratorios emergentes • Biodefensa y virus
Research projects
Content with Investigacion .
CURRENT PROJECTS: Award of the RETOS-COLABORATION 2019 Call for Proposals: Development of diagnostic kits using real-time multiplex PCR in liquid and gel format for the detection of viral diseases and sepsis.
Reference: RTC2019-007023-1 / MPY 292/20. Project funded by the Ministry of Science and Innovation and the State Research Agency.
PI: Inmaculada Casas and Giovanni Fedele.
Execution dates: 2020-2023.
Amount financed: 442,653 €.
Collaborator: Francisco Pozo
Publications
Dynamics of a Sporadic Nosocomial Acinetobacter calcoaceticus-Acinetobacter baumannii Complex Population
Villalón P, Ortega M, Sáez-Nieto JA, Carrasco G, Medina-Pascual MJ, Garrido N, Valdezate S. (2019). Dynamics of a Sporadic Nosocomial Acinetobacter calcoaceticus-Acinetobacter baumannii Complex Population. 2019. Front Microbiol. 22;10:593
PUBMED DOIEvolution of broadly cross-reactive HIV-1-neutralizing activity: therapy-associated decline, positive association with detectable viremia, and partial restoration of B-cell subpopulations
Ferreira CB, Merino-Mansilla A, Llano A, Perez I, Crespo I, Llinas L, Garcia F, Gatell JM, Yuste E, Sanchez-Merino V; J Virol. 2013 Nov;87(22):12227-36
PUBMED DOICOVID-19 Associated Pulmonary Aspergillosis (CAPA): Hospital or Home Environment as a source of life-threatening Aspergillus fumigatus infection?
Peláez-García de la Rasilla T, González-Jiménez I, García-Fernández Arroyo A, Roldán A, Carretero-Ares JL, Clemente-García M,, Martínez-Suarez M, Vázquez Valdés F, Melón-Garcia S, Mellado E, Sánchez-Nuñez ML on behalf HUCAPA group. Journal of Fungi, 2022 Mar 19;8(3):316.
PUBMED DOIRevisiting the Ancylostoma caninum secretome provides new information on hookworm-host interactions.
Morante T, Shepherd C, Constantinoiu C, Loukas A, Sotillo J. Revisiting the Ancylostoma caninum secretome provides new information on hookworm-host interactions. Proteomics. 2017 Dec;17(23-24).
PUBMED DOINrf2 plays a protective role against intravascular hemolysis-mediated acute kidney injury.
Rubio-Navarro A, Vázquez-Carballo C, Guerrero-Hue M, García-Caballero C, Herencia C, Gutierrez E, Yuste C, Sevillano A, Praga M, Egea J, Cannata P, Cortegano I, de Andrés B, Gaspar ML, Cadenas S, Michalska P, León R, Ortiz, A, Egido J, Moreno JA. Front Pharmacol. 2019; 10: 740.
PUBMED DOIEpidemiology and susceptibility to antimicrobial agents of the main Nocardia species in Spain.
Valdezate S, Garrido N, Carrasco G, Medina-Pascual MJ, Villalón P, Navarro AM, Saéz-Nieto JA. Epidemiology and susceptibility to antimicrobial agents of the main Nocardia species in Spain. J Antimicrob Chemother. 2017;72(3):754-761.
PUBMED DOIBroth microdilution protocol for determining antimicrobial susceptibility of Legionella pneumophila to clinically relevant antimicrobials
Sewell M, Farley C, Portal EAR, Lindsay D, Ricci ML, Jarraud S, Scaturro M, Descours G, Krøvel AV, Barton R, Boostom I, Ure R, Kese D, Gaia V, Golob M, Paukner S, Ginevra C, Afshar B, Nadarajah S, Wybo I, Michel C, Echahdi F, González-Rubio JM, González-Camacho F, Mentasti M, Flountzi AS, Petzold M, Moran-Gilad J, Uldum S, Winchell J, Wooton M, Bernard K, Jones LC, Chalker VJ, Spiller OB. J Microbiol Methods. 2025 Jan;228:107071.
PUBMED DOIPaenibacillus spp. isolated from human and environmental samples in Spain: detection of 11 new species.
Sáez-Nieto JA, Medina-Pascual MJ, Carrasco G, Garrido N, Fernandez-Torres MA, Villalón P, Valdezate S. Paenibacillus spp. isolated from human and environmental samples in Spain: detection of 11 new species. New Microbes New Infect. 2017. 24;19:19-27.
PUBMED DOIDefinition of the viral targets of protective HIV-1-specific T cell responses
Mothe B, Llano A, Ibarrondo J, Daniels M, Miranda C, Zamarreno J, Bach V, Zuniga R, Perez-Alvarez S, Berger CT, Puertas MC, Martinez-Picado J, Rolland M, Farfan M, Szinger JJ, Hildebrand WH, Yang OO, Sanchez-Merino V, Brumme CJ, Brumme ZL, Heckerman D, Allen TM, Mullins JI, Gomez G, Goulder PJ, Walker BD, Gatell JM, Clotet B, Korber BT, Sanchez J, Brander C; J Transl Med. 2011 Dec 7;9:208
PUBMED DOIShortcomings of the commercial MALDI-TOF MS database and use of MLSA as an arbiter in the identification of Nocardia species
Carrasco G, de Dios Caballero J, Garrido N, Valdezate S, Cantón R, Sáez-Nieto JA. Shortcomings of the commercial MALDI-TOF MS database and use of MLSA as an arbiter in the identification of Nocardia species. Front Microbiol. 2016 21;7:542.
PUBMED DOIContent with Investigacion .
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Francisco Pozo
Científico Titular de OPIs
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Inmaculada Casas
Jefe de Grupo. Científico Titular de OPIs
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Mónica González-Esguevillas
Colaborador I+D+I de OPIs
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Mar Molinero Calamita
Colaborador I+D+I de OPIs
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María de la Montaña Iglesias Caballero
Contratado Predoctoral PFIS
List of staff
Additional Information
The Respiratory Viruses and Influenza Unit is the oldest WHO Influenza Center in our country (1968), designated as the National Influenza Center by the Ministry of Health in 1971, and is the national coordinator of the CCAA laboratories in the National Influenza Surveillance Network of the Influenza Surveillance System in Spain.
Its general objective is virological surveillance, detection and control of influenza in Spain. Since 1992, together with the Pediatric Service of the Severo Ochoa Hospital, a line of research has been developed based on the etiological study of viral respiratory infections in hospitalized children.
Since 2015, the La Paz Children's University Hospital and the Immunology Laboratory of the IIS-Fundación Jiménez Díaz have also participated, expanding the study to newborns and neonatal units.
To comprehensively study respiratory viruses and the response of the immune system in viral respiratory infections that affect newborns and pediatric patients.
Deepen the knowledge of the biological properties of the viruses involved in the disease: dependency/facilitation, balance between viruses and their adaptation in multiple infections, relationship with severity, existence of virome imbalance.
The Respiratory Viruses and Influenza Unit is the oldest WHO Influenza Center in our country (1968), designated as the National Influenza Center by the Ministry of Health in 1971, and is the national coordinator of the CCAA laboratories in the National Influenza Surveillance Network of the Influenza Surveillance System in Spain.
Its general objective is virological surveillance, detection and control of influenza in Spain. Since 1992, together with the Pediatric Service of the Severo Ochoa Hospital, a line of research has been developed based on the etiological study of viral respiratory infections in hospitalized children.
Since 2015, the La Paz Children's University Hospital and the Immunology Laboratory of the IIS-Fundación Jiménez Díaz have also participated, expanding the study to newborns and neonatal units.
To comprehensively study respiratory viruses and the response of the immune system in viral respiratory infections that affect newborns and pediatric patients.
Deepen the knowledge of the biological properties of the viruses involved in the disease: dependency/facilitation, balance between viruses and their adaptation in multiple infections, relationship with severity, existence of virome imbalance.