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Investigación

Toxoplasmosis and intestinal protozoa

Líneas de investigación

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Toxoplasmosis y Protozoos intestinales

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Glycosylation of gp41 of simian immunodeficiency virus shields epitopes that can be targets for neutralizing antibodies

Yuste E, Bixby J, Lifson J, Sato S, Johnson W, Desrosiers R*. 2008. J Virol 82:12472-86.

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The fluoroquinolone levofloxacin triggers the transcriptional activation of iron transport genes that contribute to cell death in Streptococcus pneumoniae.

Ferrándiz MJ, de la Campa AG. Antimicrob Agents Chemother. 58:247-257 (2014)

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The formation of titan cells in Cryptococcus neoformans depends on the mouse strain and correlates with induction of Th2-type responses

García-Barbazán, I., Trevijano-Contador, N., Rueda, C., de Andrés, B., Pérez-Tavárez, R., Herrero-Fernández, I., Gaspar ML., and Zaragoza, O. Cellular Microbiology (2015) 18:111-124

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Simian immunodeficiency virus engrafted with human immunodeficiency virus type 1 (HIV-1)-specific epitopes: replication, neutralization, and survey of HIV-1-positive plasma

Yuste E, Sanford HB, Carmody J, Bixby J, Little S, Zwick MB, Greenough T, Burton DR, Richman DD, Desrosiers RC, Johnson WE*. 2006. J Virol 80:3030-41.

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DNGR-1+ dendritic cells are located in meningeal and choroid plexus membranes of the non-injured brain.

Quintana, E., Fernández. A, de Andrés, B., Liste, I., Sancho, D., Gaspar, ML. and Cano, E. Glia (2015) 62 (12):2231-2248

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Fluoroquinolone-resistant pneumococci: dynamics of serotypes and clones in Spain in 2012 compared with those from 2002 and 2006

Domenech A, Tirado-Vélez JM, Fenoll A, Ardanuy C, Yuste J, Liñares J, de la Campa AG. Antimicrob Agents Chemother. 58:2393-2399 (2014).

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Balancing selection and the evolution of functional polymorphism in Old World monkey TRIM5alpha

Newman RM, Hall L, Connole M, Chen GL, Sato S, Yuste E, Diehl W, Hunter E, Kaur A, Miller GM, Johnson WE; Proc Natl Acad Sci U S A. 2006 Dec 12;103(50):19134-9

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Postnatal and adult immunoglobulin repertoires of innate-like CD19(+)CD45R(lo) B Cells.

Prado, C., Rodriguez, M., Cortegano I., Ruiz, C., Alía, M., de Andrés, B., Gaspar, ML. J Inn Inmmunol. (2014) 6: 499-514

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Content with Investigacion Toxoplasmosis y Protozoos intestinales .

List of staff

Información adicional

Our group carries out research studies in the diagnosis, reference and epidemiology of zoonoses and emerging diseases, both indigenous and imported, caused by protozoa. Coordinates the study in the human field with the relevance of the animal field and the environment (One Health initiative), with special interest in Toxoplasmosis, a highly prevalent zoonosis (WHO lists it as the 3rd food-borne zoonosis in Europe), presents a complex epidemiological cycle and causes neurological, ocular and systemic symptoms. We carry out diagnostic and characterization studies of Toxoplasma gondii from human and animal cases, to obtain greater epidemiological information and analyze the possible relationship with virulence and pathology.

Cryptosporidium, Giardia, Blastocystis and Entamoeba histolytica cause gastrointestinal diseases, affecting children, immunosuppressed people and travelers. They can cause outbreaks.  We develop diagnostic and characterization studies of isolates from humans and animals, from different areas and countries, to establish the presence of the main species and genotypes and the epidemiological situation. We are beginning the study of associations between these parasites and the intestinal microbiota.

The pathogenic Free-Living Amoebas, Acanthamoeba, Naegleria fowleri and Balamuthia mandrillaris, cause emerging diseases, highlighting the importance of the environment in transmission. They cause underdiagnosed neurological and ocular cases. The diagnostic and genotyping study of human and animal isolates that we are carrying out aims to establish the real prevalence, transmission routes and epidemiology.

Content with Investigacion Toxoplasmosis y Protozoos intestinales .

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