We protect your health through science
Investigación
Toxoplasmosis and intestinal protozoa
Publicaciones destacadas
IL-7 Induces SAMHD1 Phosphorylation in CD4+ T Lymphocytes, Improving Early Steps of HIV-1 Life Cycle
IL-7 Induces SAMHD1 Phosphorylation in CD4+ T Lymphocytes, Improving Early Steps of HIV-1 Life Cycle. Coiras M, Bermejo M, Descours B, Mateos E, García-Pérez J, López-Huertas MR, Lederman MM, Benkirane M, Alcamí J. Cell Rep. 2016;14(9):2100-2107.
PUBMED DOIPKCθ and HIV-1 Transcriptional Regulator Tat Co-exist at the LTR Promoter in CD4(+) T Cells
PKCθ and HIV-1 Transcriptional Regulator Tat Co-exist at the LTR Promoter in CD4(+) T Cells. López-Huertas MR, Li J, Zafar A, Rodríguez-Mora S, García-Domínguez C, Mateos E, Alcamí J, Rao S, Coiras M. Front Immunol. 2016;7:69.
PUBMED DOIHydroxytyrosol: a new class of microbicide displaying broad anti-HIV-1 activity.
Hydroxytyrosol: a new class of microbicide displaying broad anti-HIV-1 activity. Bedoya LM, Beltrán M, Obregón-Calderón P, García-Pérez J, de la Torre HE, González N, Pérez-Olmeda M, Auñón D, Capa L, Gómez-Acebo E, Alcamí J. AIDS. 2016 Nov 28;30(18):2767-2776.
PUBMED DOIDifferent Expression of Interferon-Stimulated Genes in Response to HIV-1 Infection in Dendritic Cells Based on Their Maturation State
Different Expression of Interferon-Stimulated Genes in Response to HIV-1 Infection in Dendritic Cells Based on Their Maturation State. Calonge E, Bermejo M, Diez-Fuertes F, Mangeot I, González N, Coiras M, Jiménez Tormo L, García-Perez J, Dereuddre-Bosquet N, Le Grand R, Alcamí J. J Virol. 2017;91(8). pii: e01379-16.
PUBMED DOICharacterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors
Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors. González N, McKee K, Lynch RM, Georgiev IS, Jimenez L, Grau E, Yuste E, Kwong PD, Mascola JR, Alcamí J. PLoS One. 2018;13:e0193773.
PUBMED DOIDeep-Sequencing Analysis of the Dynamics of HIV-1 Quasiespecies in Naive Patients during a Short Exposure to Maraviroc
Deep-Sequencing Analysis of the Dynamics of HIV-1 Quasiespecies in Naive Patients during a Short Exposure to Maraviroc. Cascajero A, Rastrojo A, Díez-Fuertes F, Hernández-Novoa B, Aguado B, Moreno S, Alcami J, Pérez-Olmeda M. J Virol. 2018;92. pii: e00390-18.
PUBMED DOIEvaluation of resistance to HIV-1 infection ex vivo of PBMCs isolated from patients with chronic myeloid leukemia treated with different tyrosine kinase inhibitors.
Evaluation of resistance to HIV-1 infection ex vivo of PBMCs isolated from patients with chronic myeloid leukemia treated with different tyrosine kinase inhibitors. Bermejo M, Ambrosioni J, Bautista G, Climent N, Mateos E, Rovira C, Rodríguez-Mora S, López-Huertas MR, García-Gutiérrez V, Steegmann JL, Duarte R, Cervantes F, Plana M, Miró JM, Alcamí J, Coiras M. Biochem Pharmacol. 2018;156:248-264.
PUBMED DOIDiverse large HIV-1 non-subtype B clusters are spreading among men who have sex with men in Spain
Delgado E, Benito S, Montero V, Cuevas MT, Fernández-García A, Sánchez-Martínez M, García-Bodas E, Díez-Fuertes F, Gil H, Cañada J, Carrera C, Martínez-López J, Sintes M, Pérez-Álvarez L, Thomson MM; Spanish Group for the Study of New HIV Diagnoses. Diverse large HIV-1 non-subtype B clusters are spreading among men who have sex with men in Spain. Front Microbiol. 2019; 3;10:655.
PUBMED DOIContent with Investigacion .
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Isabel de Fuentes Corripio
Jefa de Unidad, Investigador Titular OPIS
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David González Barrio
Investigador contratado
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Marta Hernández de Mingo
Colaborador I+D+I
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David Carmena Jiménez
Investigador Doctor distinguido
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Aly Salimo Omar Muadica
Becario pre-doctoral
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Begoña Bailo Cardoso
Técnico de Laboratorio
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María Aguilera
Técnico de laboratorio
List of staff
Información adicional
Our group carries out research studies in the diagnosis, reference and epidemiology of zoonoses and emerging diseases, both indigenous and imported, caused by protozoa. Coordinates the study in the human field with the relevance of the animal field and the environment (One Health initiative), with special interest in Toxoplasmosis, a highly prevalent zoonosis (WHO lists it as the 3rd food-borne zoonosis in Europe), presents a complex epidemiological cycle and causes neurological, ocular and systemic symptoms. We carry out diagnostic and characterization studies of Toxoplasma gondii from human and animal cases, to obtain greater epidemiological information and analyze the possible relationship with virulence and pathology.
Cryptosporidium, Giardia, Blastocystis and Entamoeba histolytica cause gastrointestinal diseases, affecting children, immunosuppressed people and travelers. They can cause outbreaks. We develop diagnostic and characterization studies of isolates from humans and animals, from different areas and countries, to establish the presence of the main species and genotypes and the epidemiological situation. We are beginning the study of associations between these parasites and the intestinal microbiota.
The pathogenic Free-Living Amoebas, Acanthamoeba, Naegleria fowleri and Balamuthia mandrillaris, cause emerging diseases, highlighting the importance of the environment in transmission. They cause underdiagnosed neurological and ocular cases. The diagnostic and genotyping study of human and animal isolates that we are carrying out aims to establish the real prevalence, transmission routes and epidemiology.