We protect your health through science
Investigación
Toxoplasmosis and intestinal protozoa
Publicaciones destacadas
Moure Z, Lara N, Marín M, Sola-Campoy PJ, Bautista V, Gómez-Bertomeu F, Gómez-Dominguez C, Pérez-Vázquez M, Aracil B, Campos J, Cercenado E, Oteo-Iglesias J; Spanish Linezolid-Resistant Enterococci Collaborating Group. Interregional spread in Spain of linezolid-resistant Enterococcus spp. Isolates carrying the optrA and poxtA genes. Int J Antimicrob Agents
Moure Z, Lara N, Marín M, Sola-Campoy PJ, Bautista V, Gómez-Bertomeu F, Gómez-Dominguez C, Pérez-Vázquez M, Aracil B, Campos J, Cercenado E, Oteo-Iglesias J; Spanish Linezolid-Resistant Enterococci Collaborating Group. Interregional spread in Spain of linezolid-resistant Enterococcus spp. Isolates carrying the optrA and poxtA genes. Int J Antimicrob Agents. 2020 Jun;55(6):105977. PUBMED. DOI.
PUBMED DOIEpidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread
4. David S, Reuter S, Harris SR, Glasner C, Feltwell T, Argimon S, Abudahab K, Goater R, Giani T, Errico G, Aspbury M, Sjunnebo S; EuSCAPE Working Group; ESGEM Study Group, Feil EJ, Rossolini GM, Aanensen DM, Grundmann H et al. Epidemic of carbapenem-resistant Klebsiella pneumoniae in Europe is driven by nosocomial spread. Nat Microbiol. 2019 Nov;4(11):1919-1929.
PUBMED DOISpanish Antibiotic Resistance Surveillance Program Collaborating Group. Characterization of Carbapenemase-Producing Klebsiella oxytoca in Spain, 2016-2017
5. Pérez-Vazquez M, Oteo-Iglesias J*, Sola-Campoy PJ, Carrizo-Manzoni H, Bautista V, Lara N, Aracil B, Alhambra A, Martínez-Martínez L, Campos J. Spanish Antibiotic Resistance Surveillance Program Collaborating Group. Characterization of Carbapenemase-Producing Klebsiella oxytoca in Spain, 2016-2017. Antimicrob Agents Chemother. 2019 May 24; 63(6).
PUBMED DOIOteo J, Mencía A, Bautista V, Pastor N, Lara N, González-González F, García-Peña FJ, Campos J. Colonization with Enterobacteriaceae-Producing ESBLs, AmpCs, and OXA-48 in Wild Avian Species
Oteo J, Mencía A, Bautista V, Pastor N, Lara N, González-González F, García-Peña FJ, Campos J. Colonization with Enterobacteriaceae-Producing ESBLs, AmpCs, and OXA-48 in Wild Avian Species, Spain 2015-2016. Microb Drug Resist. 2018. Sep;24(7):932-938. PUBMED. DOI.
PUBMEDBarrado L, Pérez-Vázquez M, Del Pozo JL, Martín-Salas C, Leiva J, Mazón A, Ezpeleta C, Oteo J. Clonal transmission of NDM-5-producing Escherichia coli belonging to high-risk sequence type ST405
Barrado L, Pérez-Vázquez M, Del Pozo JL, Martín-Salas C, Leiva J, Mazón A, Ezpeleta C, Oteo J. Clonal transmission of NDM-5-producing Escherichia coli belonging to high-risk sequence type ST405. Int J Antimicrob Agents. 2018 Jul;52(1):123-124. PUBMED. DOI.
PUBMEDGrundmann H, Glasner C, Albiger B, Aanensen DM, Tomlinson CT, Andrasević AT, Cantón R, Carmeli Y, Friedrich AW, Giske CG, Glupczynski Y, Gniadkowski M, Livermore DM, Nordmann P, Poirel L, Rossolini GM, Seifert H, Vatopoulos A, Walsh T, Woodford N, Monnet DL; European Survey of Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) Working Group. Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study
Grundmann H, Glasner C, Albiger B, Aanensen DM, Tomlinson CT, Andrasević AT, Cantón R, Carmeli Y, Friedrich AW, Giske CG, Glupczynski Y, Gniadkowski M, Livermore DM, Nordmann P, Poirel L, Rossolini GM, Seifert H, Vatopoulos A, Walsh T, Woodford N, Monnet DL; European Survey of Carbapenemase-Producing Enterobacteriaceae (EuSCAPE) Working Group. Occurrence of carbapenemase-producing Klebsiella pneumoniae and Escherichia coli in the European survey of carbapenemase-producing Enterobacteriaceae (EuSCAPE): a prospective, multinational study. Lancet Infect Dis. 2017;17(2):153‐163. D1, IP:27,516. PUBMED. DOI.
PUBMEDThe Carbapenemase-Producing Klebsiella pneumoniae Population Is Distinct and More Clonal than the Carbapenem-Susceptible Population.
7. Esteban-Cantos A, Aracil B, Bautista V, Ortega A, Lara N, Saez D, Fernández-Romero S, Pérez-Vázquez M, Navarro F, Grundmann H, Campos J, Oteo J*; EuSCAPE-Spain Network. The Carbapenemase-Producing Klebsiella pneumoniae Population Is Distinct and More Clonal than the Carbapenem-Susceptible Population. Antimicrob Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02520-16
PUBMED DOIThe spread of KPC-producing Enterobacteriaceae in Spain: WGS analysis of the emerging high-risk clones of Klebsiella pneumoniae ST11/KPC-2, ST101/KPC-2 and ST512/KPC-3
8. Oteo J*, Pérez-Vázquez M, Bautista V, Ortega A, Zamarrón P, Saez D, Fernández-Romero S, Lara N, Ramiro R, Aracil B, Campos J; Spanish Antibiotic Resistance Surveillance Program Collaborating Group. The spread of KPC-producing Enterobacteriaceae in Spain: WGS analysis of the emerging high-risk clones of Klebsiella pneumoniae ST11/KPC-2, ST101/KPC-2 and ST512/KPC-3. J Antimicrob Chemother. 2016; 71(12):3392-3399.
PUBMED DOICarbapenemase-producing Escherichia coli is becoming more prevalent in Spain mainly because of the polyclonal dissemination of OXA-48
9. Ortega A, Sáez D, Bautista V, Fernández-Romero S, Lara N, Aracil B, Pérez-Vázquez M, Campos J, Oteo J*; Spanish Collaborating Group for the Antibiotic Resistance Surveillance Programme. Carbapenemase-producing Escherichia coli is becoming more prevalent in Spain mainly because of the polyclonal dissemination of OXA-48. J Antimicrob Chemother. 2016; 71(8):2131-8.
PUBMED DOICurso de Gestión de Calidad y Buenas Prácticas de Laboratorio. Ed. 3
Grammatico JP, Cuevas L (Edits.) y Grupo de expertos de la Organización Panamericana de la Salud OPS/OMS. Curso de Gestión de Calidad y Buenas Prácticas de Laboratorio. Ed. 3. OPS/OMS;. Washington, D.C., 2016. Disponible en: “http://iris.paho.org/xmlui/handle/123456789/31168”. ISBN: 978-92-75-11906-8
Gestión de la Calidad para laboratorios de ensayo. 1ª ed.
Grammatico JP, Cuevas L (Edits.). Gestión de la Calidad para laboratorios de ensayo. 1ª ed. Conicet-Madri+d; Buenos Aires, 2011. Disponible en: “http://www.madrimasd.org/Laboratorios/Documentos/Red-Laboratorios/documentos/Gest_Calidad_Ensayo.pdf”. ISBN: 978-950-692-095-1
Curso de Gestión de Calidad y Buenas Prácticas de Laboratorio.
Grupo de expertos de la Organización Panamericana de la Salud OPS/OMS. Curso de Gestión de Calidad y Buenas Prácticas de Laboratorio. OPS; Documentos Técnicos THR/HT 2009/001. Washington, D.C., 2009. ISBN: 978-92-75-32977-1
Guía Latinoamericana para la implementación de Código de Ética en los laboratorios de salud.
Grupo de expertos de la Organización Panamericana de la Salud (OPS/OMS). Guía Latinoamericana para la implementación de Código de Ética en los laboratorios de salud. Organización Panamericana de la Salud. Documentos Técnicos. Políticas y Regulación. THS/EV-2007/001; 2007. ISBN: 92-7-532702-5
Guiding the humoral response against HIV-1 toward a MPER adjacent region by immunization with a VLP-formulated antibody-selected envelope variant.
Guiding the humoral response against HIV-1 toward a MPER adjacent region by immunization with a VLP-formulated antibody-selected envelope variant. Beltran-Pavez C, Ferreira CB, Merino-Mansilla A, Fabra-Garcia A, Casadella M, Noguera-Julian M, Paredes R, Olvera A, Haro I, Brander C, Garcia F, Gatell JM, Yuste E, Sanchez-Merino V. PLoS One. 2018;13:e0208345.
PUBMED DOIStructure-based design of an RNA-binding p-terphenylene scaffold that inhibits HIV-1 Rev protein function.
tructure-based design of an RNA-binding p-terphenylene scaffold that inhibits HIV-1 Rev protein function. González-Bulnes L, Ibáñez I, Bedoya LM, Beltrán M, Catalán S, Alcamí J, Fustero S, Gallego J. Angew Chem Int Ed Engl. 2013;52:13405-9
PUBMED DOIA single-residue change in the HIV-1 V3 loop associated with maraviroc resistance impairs CCR5 binding affinity while increasing replicative capacity.
A single-residue change in the HIV-1 V3 loop associated with maraviroc resistance impairs CCR5 binding affinity while increasing replicative capacity. Garcia-Perez J, Staropoli I, Azoulay S, Heinrich JT, Cascajero A, Colin P, Lortat-Jacob H, Arenzana-Seisdedos F, Alcami J, Kellenberger E, Lagane B. Retrovirology. 2015;12:50.
PUBMED DOIIL-7 Induces SAMHD1 Phosphorylation in CD4+ T Lymphocytes, Improving Early Steps of HIV-1 Life Cycle
IL-7 Induces SAMHD1 Phosphorylation in CD4+ T Lymphocytes, Improving Early Steps of HIV-1 Life Cycle. Coiras M, Bermejo M, Descours B, Mateos E, García-Pérez J, López-Huertas MR, Lederman MM, Benkirane M, Alcamí J. Cell Rep. 2016;14(9):2100-2107.
PUBMED DOIPKCθ and HIV-1 Transcriptional Regulator Tat Co-exist at the LTR Promoter in CD4(+) T Cells
PKCθ and HIV-1 Transcriptional Regulator Tat Co-exist at the LTR Promoter in CD4(+) T Cells. López-Huertas MR, Li J, Zafar A, Rodríguez-Mora S, García-Domínguez C, Mateos E, Alcamí J, Rao S, Coiras M. Front Immunol. 2016;7:69.
PUBMED DOIHydroxytyrosol: a new class of microbicide displaying broad anti-HIV-1 activity.
Hydroxytyrosol: a new class of microbicide displaying broad anti-HIV-1 activity. Bedoya LM, Beltrán M, Obregón-Calderón P, García-Pérez J, de la Torre HE, González N, Pérez-Olmeda M, Auñón D, Capa L, Gómez-Acebo E, Alcamí J. AIDS. 2016 Nov 28;30(18):2767-2776.
PUBMED DOIDifferent Expression of Interferon-Stimulated Genes in Response to HIV-1 Infection in Dendritic Cells Based on Their Maturation State
Different Expression of Interferon-Stimulated Genes in Response to HIV-1 Infection in Dendritic Cells Based on Their Maturation State. Calonge E, Bermejo M, Diez-Fuertes F, Mangeot I, González N, Coiras M, Jiménez Tormo L, García-Perez J, Dereuddre-Bosquet N, Le Grand R, Alcamí J. J Virol. 2017;91(8). pii: e01379-16.
PUBMED DOIContent with Investigacion .
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Isabel de Fuentes Corripio
Jefa de Unidad, Investigador Titular OPIS
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David González Barrio
Investigador contratado
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Marta Hernández de Mingo
Colaborador I+D+I
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David Carmena Jiménez
Investigador Doctor distinguido
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Aly Salimo Omar Muadica
Becario pre-doctoral
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Begoña Bailo Cardoso
Técnico de Laboratorio
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María Aguilera
Técnico de laboratorio
List of staff
Información adicional
Our group carries out research studies in the diagnosis, reference and epidemiology of zoonoses and emerging diseases, both indigenous and imported, caused by protozoa. Coordinates the study in the human field with the relevance of the animal field and the environment (One Health initiative), with special interest in Toxoplasmosis, a highly prevalent zoonosis (WHO lists it as the 3rd food-borne zoonosis in Europe), presents a complex epidemiological cycle and causes neurological, ocular and systemic symptoms. We carry out diagnostic and characterization studies of Toxoplasma gondii from human and animal cases, to obtain greater epidemiological information and analyze the possible relationship with virulence and pathology.
Cryptosporidium, Giardia, Blastocystis and Entamoeba histolytica cause gastrointestinal diseases, affecting children, immunosuppressed people and travelers. They can cause outbreaks. We develop diagnostic and characterization studies of isolates from humans and animals, from different areas and countries, to establish the presence of the main species and genotypes and the epidemiological situation. We are beginning the study of associations between these parasites and the intestinal microbiota.
The pathogenic Free-Living Amoebas, Acanthamoeba, Naegleria fowleri and Balamuthia mandrillaris, cause emerging diseases, highlighting the importance of the environment in transmission. They cause underdiagnosed neurological and ocular cases. The diagnostic and genotyping study of human and animal isolates that we are carrying out aims to establish the real prevalence, transmission routes and epidemiology.