We protect your health through science
Investigación
Toxoplasmosis and intestinal protozoa
Publicaciones destacadas
High levels of anti-Phlebotomus perniciosus saliva antibodies in different reservoirs from the re-emerging leishmaniasis focus in Madrid, Spain.
2. Martín-Martín I, Molina R, Rohoušová I, Drahota J., Volf P, Jiménez M. High levels of anti-Phlebotomus perniciosus saliva antibodies in different reservoirs from the re-emerging leishmaniasis focus in Madrid, Spain. Vet Parasitol 2014, 202: 207–216.
PUBMED DOICould wild rabbits (Oryctolagus cuniculus) be reservoirs for Leishmania infantum in the focus of Madrid, Spain?
3. Jiménez M, González E, Martín-Martín I, Hernández S, Molina R. Could wild rabbits (Oryctolagus cuniculus) be reservoirs for Leishmania infantum in the focus of Madrid, Spain?. Vet Parasitol 2014, 202: 296–300.
PUBMED DOIReview of ten-years presence of Aedes albopictus in Spain 2004–2014: known distribution and public health concerns.
5. Collantes F, Delacour S, Alarcón-Elbal PM, Ruiz-Arrondo I, Delgado JA, Torrell-Sorio A, Bengoa M, Eritja R, Miranda MA, Molina R, Lucientes J. Review of ten-years presence of Aedes albopictus in Spain 2004–2014: known distribution and public health concerns. Parasit Vectors. 2015 Dec 23;8:655.
PUBMED DOIPhleboviruses detection in Phlebotomus perniciosus from a human leishmaniasis focus in South-West Madrid region, Spain.
6. Remoli ME, Jiménez M, Fortuna C, Benedetti E, Marchi A, Genovese D, Gramiccia M, Molina R, Ciufolini MG. Phleboviruses detection in Phlebotomus perniciosus from a human leishmaniasis focus in South-West Madrid region, Spain. Parasit Vectors 2016, 9:205.
PUBMED DOIInfectivity of Post-Kala-azar Dermal Leishmaniasis patients to sand flies: revisiting a proof of concept in the context of the Kala-azar Elimination Program in the Indian subcontinent.
7. Molina R, Ghosh D, Carrillo E, Monnerat S, Bern C, Mondal D, Alvar J. Infectivity of Post-Kala-azar Dermal Leishmaniasis patients to sand flies: revisiting a proof of concept in the context of the Kala-azar Elimination Program in the Indian subcontinent. Clin Infect Dis 2017, 65:
PUBMED DOIPrevalence and molecular characterization of Strongyloides stercoralis, Giardia duodenalis, Cryptosporidium spp., and Blastocystis spp. isolates in schoolchildren in Cubal, Central Angola
2. Dacal E, Saugar JM, de Lucio A, Hernández de Mingo M, Robinson E, Aznar Ruiz de Alegría ML, Espasa M, Ninda A, Gandasegui J, Sulleiro E, Moreno M, Salvador F, Molina I, Rodríguez E, Carmena D. 2018. Prevalence and molecular characterization of Strongyloides stercoralis, Giardia duodenalis, Cryptosporidium spp., and Blastocystis spp. isolates in schoolchildren in Cubal, Central Angola. Parasites and Vectors, 11: 67.
PUBMED DOIMolecular diversity and frequency of the diarrheagenic enteric protozoan Giardia duodenalis and Cryptosporidium spp. in a hospital setting in Northern Spain.
3. Azcona-Gutiérrez JM, de Lucio A, Hernández-de-Mingo M, García-García C, Soria-Blanco LM, Morales L, Aguilera M, Fuentes I, Carmena D. 2017. Molecular diversity and frequency of the diarrheagenic enteric protozoan Giardia duodenalis and Cryptosporidium spp. in a hospital setting in Northern Spain. PLoS One, 12: e0178575.
PUBMED DOIDetection of zoonotic protozoa Toxoplasma gondii and Sarcocystis suihominis in wild boars from Spain. Zoonoses Public Health
4. Calero-Bernal, R., Pérez-Martín, J.E., Reina, D., Serrano, F.J., Frontera, E., Fuentes, I, Dubey, J.P., 2016. Detection of zoonotic protozoa Toxoplasma gondii and Sarcocystis suihominis in wild boars from Spain. Zoonoses Public Health. 63:346-50
PUBMED DOIEpidemiological and clinical profile of adult patients with Blastocystis sp. infection in Barcelona, Spain.
5. Salvador F, Sulleiro E, Sánchez-Montalvá A, Alonso C, Santos J, Fuentes I, Molina I. 2016; Epidemiological and clinical profile of adult patients with Blastocystis sp. infection in Barcelona, Spain. Parasit Vectors; 9:548.
PUBMED DOIPrevalence and genetic diversity of Giardia duodenalis and Cryptosporidium spp. among schoolchildren in a rural area of the Amhara Region, North-West Ethiopia
6. de Lucio A, Amor-Aramendía A, Bailo B, Saugar JM, Anegagrie M, Arroyo A, López-Quintana B, Zewdie D, Ayehubizu Z, Yizengaw E, Abera B, Yimer M, Mulu W, Hailu T, Herrador Z, Fuentes I, Carmena D. 2016. Prevalence and genetic diversity of Giardia duodenalis and Cryptosporidium spp. among schoolchildren in a rural area of the Amhara Region, North-West Ethiopia. PLoS One 11: e0159992.
PUBMED DOIPrevalence and genotype identification of Toxoplasma gondii in wild animals from southwestern Spain.
8. Calero-Bernal R, Saugar JM, Frontera E, Pérez-Martín JE, Habela MA, Serrano FJ, Reina D, Fuentes I. 2015. Prevalence and genotype identification of Toxoplasma gondii in wild animals from southwestern Spain. J Wildl Dis, 51:233-8.
PUBMED DOIHigh SARS-CoV-2 Viral Load and Low CCL5 Expression Levels in the Upper Respiratory Tract Are Associated With COVID-19 Severity.
4. Pérez-García F, Martin-Vicente M, Rojas-García RL, Castilla-García L, Muñoz-Gomez MJ, Hervás-Fernández I, González-Ventosa V, Vidal-Alcántara EJ, Cuadros-González J, Bermejo-Martin JF (‡), Resino S (‡ *), Martínez I (‡). High SARS-CoV-2 Viral Load and Low CCL5 Expression Levels in the Upper Respiratory Tract Are Associated With COVID-19 Severity. J Infect Dis 2022; 225(6):977-982 (A; FI= 7.76; Q1, Infectious Diseases; JCR 2021). PMID: 34910814 DOI: 10.1093/infdis/jiab604.
PUBMED DOIMetabolomic changes after DAAs therapy are related to the improvement of cirrhosis and inflammation in HIV/HCV-coinfected patients.
5. Virseda-Berdices A, Rojo D, Martínez I, Berenguer J, González-García J, Brochado-Kith O, Fernández-Rodríguez A, Díez C, Hontañon V, Pérez-Latorre L, Micán R, Barbas C, Resino S (‡ *), Jiménez-Sousa MA (‡ *). Metabolomic changes after DAAs therapy are related to the improvement of cirrhosis and inflammation in HIV/HCV-coinfected patients. Biomed Pharmacother 2022, 147: 112626. (A; FI= 7.42; D1, Pharmacology & Pharmacy; JCR 2021).
PUBMED DOIBlood microbiome is associated with changes in portal hypertension after successful direct-acting antiviral therapy in patients with HCV-related cirrhosis.
7. Virseda-Berdices A, Brochado-Kith O, Díez C, Hontañon V, Berenguer J, González-García J, Rojo D, Fernández-Rodríguez A, Ibañez-Samaniego L, Llop-Herrera E, Olveira A, Perez-Latorre L, Barbas C, Rava M (‡), Resino S (‡ *), Jiménez-Sousa MA (‡ *). Blood microbiome is associated with changes in portal hypertension after successful direct-acting antiviral therapy in patients with HCV-related cirrhosis. J Antimicrob Chemoth 2022; 77 (3): 719–726 (A; FI= 5.76; Q1, Pharmacology & Pharmacy; JCR 2020).
PUBMED DOIPotential impact of the 4CMenB vaccine on oropharyngeal carriage of Neisseria meningitidis
2. Abad R, Médina V, Fariñas MC, Martinez-Martinez L, Bambini S, Dari A, Medini D, Pizza M, Vázquez J. “Potential impact of the 4CMenB vaccine on oropharyngeal carriage of Neisseria meningitidis”. J Infect. 2017 Dec:75(6):511-520.
PUBMED DOIWGS analysis and molecular resistance mechanisms of azithromycin-resistant (MIC >2 mg/L) Neisseria gonorrhoeae isolates in Europe from 2009 to 2014
4. Jacobsson S, Golparian D, Cole M, Spiteri G, Martin I, Bergheim T, Borrego MJ, Crowley B, Crucitti T, Van Dam AP, Hoffmann S, Jeverica S, Kohl P, Mlynarczyk-Bonikowska B, Pakarna G, Stary A, Stefanelli P, Pavlik P, Tzelepi E, Abad R, Harris SR, Unemo M. “WGS analysis and molecular resistance mechanisms of azithromycin-resistant (MIC >2 mg/L) Neisseria gonorrhoeae isolates in Europe from 2009 to 2014.” J. Antimicrob. Chemother. (2016) 71 (11): 3109-3116.
PUBMED DOIPredicted Strain Coverage of a New Meningococcal Multicomponent Vaccine (4CMenB) in Spain: Analysis of the Differences with Other European Countrie
5. Abad R, Medina V, Stella M, Boccadifuoco G, Comanducci M, Bambini S, Muzzi A, Vázquez JA. “Predicted Strain Coverage of a New Meningococcal Multicomponent Vaccine (4CMenB) in Spain: Analysis of the Differences with Other European Countries.” PLoS One. 2016 Mar 7;11(3):e0150721.
PUBMED DOIA large portion of MATS negative meningococcal strains from Spain are killed by sera from adolescents and infants immunized with 4CMenB
6. Abad R, Biolchi A, Moschioni M, Giuliani MM, Pizza M, Vázquez JA. “A large portion of MATS negative meningococcal strains from Spain are killed by sera from adolescents and infants immunized with 4CMenB”. Clin Vaccine Immunol. 2015 April; 22(4): 357-60.
PUBMED DOISerogroup W meningococcal disease: global spread and currently affecting the southern cone in Latin America
7. Abad R, López EL, Debbag R, Vázquez JA. “Serogroup W meningococcal disease: global spread and currently affecting the southern cone in Latin America”. Epidemiol Infect. 2014 Dec; 142(12): 2461-2470.
PUBMED DOIContent with Investigacion .
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Isabel de Fuentes Corripio
Jefa de Unidad, Investigador Titular OPIS
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David González Barrio
Investigador contratado
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Marta Hernández de Mingo
Colaborador I+D+I
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David Carmena Jiménez
Investigador Doctor distinguido
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Aly Salimo Omar Muadica
Becario pre-doctoral
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Begoña Bailo Cardoso
Técnico de Laboratorio
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María Aguilera
Técnico de laboratorio
List of staff
Información adicional
Our group carries out research studies in the diagnosis, reference and epidemiology of zoonoses and emerging diseases, both indigenous and imported, caused by protozoa. Coordinates the study in the human field with the relevance of the animal field and the environment (One Health initiative), with special interest in Toxoplasmosis, a highly prevalent zoonosis (WHO lists it as the 3rd food-borne zoonosis in Europe), presents a complex epidemiological cycle and causes neurological, ocular and systemic symptoms. We carry out diagnostic and characterization studies of Toxoplasma gondii from human and animal cases, to obtain greater epidemiological information and analyze the possible relationship with virulence and pathology.
Cryptosporidium, Giardia, Blastocystis and Entamoeba histolytica cause gastrointestinal diseases, affecting children, immunosuppressed people and travelers. They can cause outbreaks. We develop diagnostic and characterization studies of isolates from humans and animals, from different areas and countries, to establish the presence of the main species and genotypes and the epidemiological situation. We are beginning the study of associations between these parasites and the intestinal microbiota.
The pathogenic Free-Living Amoebas, Acanthamoeba, Naegleria fowleri and Balamuthia mandrillaris, cause emerging diseases, highlighting the importance of the environment in transmission. They cause underdiagnosed neurological and ocular cases. The diagnostic and genotyping study of human and animal isolates that we are carrying out aims to establish the real prevalence, transmission routes and epidemiology.