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Investigation
Measles, rubella, mumps, parvovirus B19 and rabies
Research projects
Content with Investigacion .
Los proyectos del grupo de los últimos años son los siguientes:
Proyecto “Enfoques inmunoinformaticos e inmunoproteomicos para identificar epitopos bacterianos implicados en la REA: diagnostico temprano y diseño de farmacos” financiado por el Plan Nacional de I+D+i del Ministerio de Ciencia, Innovación y Universidades. Centro Nacional de Microbiología, Instituto de Salud Carlos III. Investigador principal. Año: 2024-2026. Presupuesto Concedido: 225.000 euros. Proyecto PID2023-148729OB-100 financiado por MICIU/AEI/10.13039/501100011033 y por FEDER, UE.
Proyecto “La interrelación de CD69 y el procesamiento antigénico en enfermedades infecciosas y autoinmunes" financiado por la Acción Estratégica en Salud del Ministerio de Ciencia, Innovación y Universidades. Año: 2023-2025.
Proyecto “Interacciones génicas y proteicas de CD69 y sus regiones génicas reguladoras con moléculas" inanciado por el Plan Nacional de I+D+i del Ministerio de Ciencia, Innovación y Universidades. Centro Nacional de Microbiología, Instituto de Salud Carlos III. Proyecto PID2021-125757OB-100 financiado por MICIU/AEI/10.13039/501100011033 y por FEDER, UE.
Proyecto “Nuevas tecnologías de fabricación y optimización de tejidos: la piel como sistema modelo” financiado por el Programa de Actividades de I+D entre grupos de investigación de la Comunidad de Madrid en tecnologías 2018. Año: 2020-2023. Proyecto Coordinado por el Dr. Pablo Acedo de la Universidad Carlos III.
Proyecto “Estudio de CD69 como diana para mejorar el tratamiento de la leucopania y la movilización de células T de memoria de médula ósea" financiado por la Acción Estratégica en Salud del Ministerio de Ciencia, Innovación y Universidades. Año:2020-2024.
Proyecto “Diseño racional de una vacuna contra el virus respiratorio sincitial humano” financiado por la Acción Estratégica en Salud del Ministerio de Ciencia, Innovación y Universidades. Año: 2019-2022
Proyecto “Función de CD69 y sus elementos reguladores" financiado por la Acción Estratégica en Salud del Ministerio de Ciencia, Innovación y Universidades. Año: 2017-2022.
Proyecto “Diseño de vacunas recombinantes poliepitópicas para generar respuestas CD8+ contra virus emergentes” financiado por el Plan Nacional de I+D+i del Ministerio de Economía y Competitividad. Año: 2015-2017.
Proyecto “Análisis de los efectos de CD69 dependientes de S1P1 en modelos de infección e inflamación y estudio de su regulación” financiado por el FIS. Año: 2014-2017.
Proyecto “ADELVAC: Adenovirus con delecciones epitópicas para vacunación” financiado por el programa INNPACTO del Ministerio de Economía y Competitividad. Centro Nacional de Microbiología, Instituto de Salud Carlos III. Año: 2012-2014. Proyecto Coordinado por el Dr. Manel Cascallo de VCN BIOSCIENCES SL.
Proyecto “Diseño de vacunas multiepitópicas recombinantes para aumentar la respuesta inmune celular contra el VRSH” financiado por el Plan Nacional de I+D+i del Ministerio de Ciencia e Innovación. Año: 2012-2014.
Publications
9: Harvala H, Broberg E, Benschop K, Berginc N, Ladhani S, Susi P, Christiansen C, McKenna J, Allen D, Makiello P, McAllister G, Ca
9: Harvala H, Broberg E, Benschop K, Berginc N, Ladhani S, Susi P, Christiansen C, McKenna J, Allen D, Makiello P, McAllister G, Carmen M, Zakikhany K, Dyrdak R, Nielsen X, Madsen T, Paul J, Moore C, von Eije K, Piralla A, Carlier M, Vanoverschelde L, Poelman R, Anton A, López-Labrador FX, Pellegrinelli L, Keeren K, Maier M, Cassidy H, Derdas S, Savolainen-Kopra C, Diedrich S, Nordbø S, Buesa J, Bailly JL, Baldanti F, MacAdam A, Mirand A, Dudman S, Schuffenecker I, Kadambari S, Neyts J, Griffiths MJ, Richter J, Margaretto C, Govind S, Morley U, Adams O, Krokstad S, Dean J, Pons-Salort M, Prochazka B, Cabrerizo M, Majumdar M, Nebbia G, Wiewel M, Cottrell S, Coyle P, Martin J, Moore C, Midgley S, Horby P, Wolthers K, Simmonds P, Niesters H, Fischer TK. Recommendations for enterovirus diagnostics and characterisation within and beyond Europe. J Clin Virol. 2018 Apr; 101:11-17. doi: 10.1016/j.jcv.2018.01.008. Epub 2018 Feb 6. PMID: 29414181.
Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii
Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii. García-Quintanilla M, Caro-Vega JM, Pulido MR, Moreno-Martínez P, Pachón J, McConnell MJ. Antimicrob Agents Chemother. 2016 Jul 22;60(8):5076-9. doi: 10.1128/AAC.00407-16.
PUBMEDNew Panfungal Real-Time PCR Assay for Diagnosis of Invasive Fungal Infections.
4. Valero C, de la Cruz-Villar L, Zaragoza O, Buitrago MJ. New Panfungal Real-Time PCR Assay for Diagnosis of Invasive Fungal Infections. J Clin Microbiol. 2016 Dec;54(12):2910-2918. doi: 10.1128/JCM.01580-16. Epub 2016 Sep 14. PMID: 27629898.
DOIA Multiplex Real-Time PCR Assay for Identification of Pneumocystis jirovecii, Histoplasma capsulatum, and Cryptococcus neoformans/Cryptococcus gattii in Samples from AIDS Patients with Opportunistic Pneumonia
6. Gago S, Esteban C, Valero C, Zaragoza O, Puig de la Bellacasa J, Buitrago MJ. A multiplex real-time PCR assay for identification of Pneumocystis jirovecii, Histoplasma capsulatum, and Cryptococcus neoformans/Cryptococcus gattii in samples from AIDS patients with opportunistic pneumonia. J Clin Microbiol. 2014 Apr;52(4):1168-76. doi: 10.1128/JCM.02895-13. Epub 2014 Jan 29. PMID: 24478409.
PUBMED DOIAnalysis of strain relatedness using High Resolution Melting in a case of recurrent candiduria
7. Gago S, Lorenzo B, Gomez-Lopez A, Cuesta I, Cuenca-Estrella M, Buitrago MJ. Analysis of strain relatedness using high resolution melting in a case of recurrent candiduria. BMC Microbiol. 2013 Jan 23;13:13. doi: 10.1186/1471-2180-13-13. PMID: 23343107.
PUBMED DOIHigh-Resolution Melting Analysis for Identification of the Cryptococcus neoformans-Cryptococcus gattii Complex
8. Gago S, Zaragoza Ó, Cuesta I, Rodríguez-Tudela JL, Cuenca-Estrella M, Buitrago MJ. High-resolution melting analysis for identification of the Cryptococcus neoformans-Cryptococcus gattii complex. J Clin Microbiol. 2011 Oct;49(10):3663-6. doi: 10.1128/JCM.01091-11. Epub 2011 Aug 10. PMID: 21832024.
PUBMED DOIPerformance of Panfungal- and Specific-PCR-Based Procedures for Etiological Diagnosis of Invasive Fungal Diseases on Tissue Biopsy Specimens with Proven Infection: a 7-Year Retrospective Analysis from a Reference Laboratory
9. Buitrago MJ, Bernal-Martinez L, Castelli MV, Rodriguez-Tudela JL, Cuenca-Estrella M Performance of panfungal--and specific-PCR-based procedures for etiological diagnosis of invasive fungal diseases on tissue biopsy specimens with proven infection: a 7-year retrospective analysis from a reference laboratory. J Clin Microbiol. 2014 May;52(5):1737-40. doi: 10.1128/JCM.00328-14. Epub 2014 Feb 26.PMID: 24574295.
PUBMED DOIEpidemiología actual y diagnóstico de laboratorio de las micosis endémicas en España
11. Buitrago MJ, Cuenca-Estrella M. [Current epidemiology and laboratory diagnosis of endemic mycoses in Spain]. Enferm Infecc Microbiol Clin. 2012 Aug;30(7):407-13. doi: 10.1016/j.eimc.2011.09.014. Epub 2011 Nov 29. PMID: 22130575 Review. Spanish.
PUBMED DOIA matrix-assisted laser desorption/ionization time of flight mass spectrometry reference database for the identification of Histoplasma capsulatum
12. Buitrago MJ, Bernal-Martínez L, Castelli MV, Rodríguez-Tudela JL, Cuenca-Estrella M. Histoplasmosis and paracoccidioidomycosis in a non-endemic area: a review of cases and diagnosis. J Travel Med. 2011 Jan-Feb;18(1):26-33. doi: 10.1111/j.1708-8305.2010.00477.x. Epub 2010 Nov 28. PMID: 21199139.
PUBMED DOICopy Number Variation of Mitochondrial DNA Genes in Pneumocystis jirovecii According to the Fungal Load in BAL Specimens
13. Valero C, Buitrago MJ, Gago S, Quiles-Melero I, García-Rodríguez J. A matrix-assisted laser desorption/ionization time of flight mass spectrometry reference database for the identification of Histoplasma capsulatum. Med Mycol. 2018 Apr 1;56 (3):307-314. doi: 10.1093/mmy/myx047. PMID: 28992262.
PUBMED DOICopy Number Variation of Mitochondrial DNA Genes in Pneumocystis jirovecii According to the Fungal Load in BAL Specimens
14. Valero C, Buitrago MJ, Gits-Muselli M, Benazra M, Sturny-Leclère A, Hamane S, Guigue N, Bretagne S, Alanio A. Copy Number Variation of Mitochondrial DNA Genes in Pneumocystis jirovecii According to the Fungal Load in BAL Specimens. Front Microbiol. 2016 Sep 12;7:1413. doi: 10.3389/fmicb.2016.01413. eCollection 2016. PMID: 27672381.
PUBMED DOIIdentification of Off-Patent Compounds That Present Antifungal Activity Against the Emerging Fungal Pathogen Candida auris
2: de Oliveira HC, Monteiro MC, Rossi SA, Pemán J, Ruiz-Gaitán A, Mendes- Giannini MJS, Mellado E, Zaragoza O. Identification of Off-Patent Compounds That Present Antifungal Activity Against the Emerging Fungal Pathogen Candida auris. Front Cell Infect Microbiol. 2019 Apr 2;9:83. PMCID: PMC6454888.
PUBMED DOICryptococcus neoformans can form titan-like cells in vitro in response to multiple signals
Trevijano-Contador N, de Oliveira HC, García-Rodas R, Rossi SA, Llorente I, Zaballos Á, Janbon G, Ariño J, Zaragoza Ó. Cryptococcus neoformans can form titan-like cells in vitro in response to multiple signals. PLoS Pathog. 2018 May 18;14(5):e1007007. PMCID: PMC6454888.
PUBMED DOICell Wall Changes in Amphotericin B-Resistant Strains from Candida tropicalis and Relationship with the Immune Responses Elicited by the Host
5: Mesa-Arango AC, Rueda C, Román E, Quintin J, Terrón MC, Luque D, Netea MG, Pla J, Zaragoza O. Cell Wall Changes in Amphotericin B-Resistant Strains from Candida tropicalis and Relationship with the Immune Responses Elicited by the Host. Antimicrob Agents Chemother. 2016 Mar 25;60(4):2326-35. PMCID: PMC4808153.
PUBMED DOIThe production of reactive oxygen species is a universal action mechanism of Amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this drug
8: Mesa-Arango AC, Trevijano-Contador N, Román E, Sánchez-Fresneda R, Casas C, Herrero E, Argüelles JC, Pla J, Cuenca-Estrella M, Zaragoza O. The production of reactive oxygen species is a universal action mechanism of Amphotericin B against pathogenic yeasts and contributes to the fungicidal effect of this drug. Antimicrob Agents Chemother. 2014 Nov;58(11):6627-38. PMCID: PMC4249417.
PUBMED DOICapsule Growth in Cryptococcus neoformans Is Coordinated with Cell Cycle Progression
9: García-Rodas R, Cordero RJ, Trevijano-Contador N, Janbon G, Moyrand F, Casadevall A, Zaragoza O. Capsule growth in Cryptococcus neoformans is coordinated with cell cycle progression. mBio. 2014 Jun 17;5(3):e00945-14. PMCID: PMC4056547.
PUBMED DOIThe interaction between Candida krusei and murine macrophages results in multiple outcomes, including intracellular survival and escape from killing
12: García-Rodas R, González-Camacho F, Rodríguez-Tudela JL, Cuenca-Estrella M, Zaragoza O. The interaction between Candida krusei and murine macrophages results in multiple outcomes, including intracellular survival and escape from killing. Infect Immun. 2011 Jun;79(6):2136-44. PMCID: PMC3125833.
PUBMED DOIHuman IgM Inhibits the Formation of Titan-Like Cells in Cryptococcus neoformans
14: Trevijano-Contador N, Pianalto KM, Nichols CB, Zaragoza O, Alspaugh JA, Pirofski LA. Human IgM Inhibits the Formation of Titan-Like Cells in Cryptococcus neoformans. Infect Immun. 2020 Mar 23;88(4):e00046-20. PMCID: PMC7093138.
PUBMED DOIThe lymphocyte scavenger receptor CD5 plays a nonredundant role in fungal infection
15: Velasco-de-Andrés M, Català C, Casadó-Llombart S, Simões I, Zaragoza O, Carreras E, Lozano F. The lymphocyte scavenger receptor CD5 plays a nonredundant role in fungal infection. Cell Mol Immunol. 2020 Apr 24.
PUBMED DOIContent with Investigacion .
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Begoña Galocha Iragüen
Científico Titular
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Pilar Lauzurica Gómez
Investigador Principal
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Daniel López Rodríguez
Investigador Principal
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Elena Lorente Galán
Técnico Especializado de OPIS
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Almudena Albentosa Cocho
Ayudante de Investigación
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Carmen Mir Guerrero
Técnico de Laboratorio
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Miguel Gómez Fontela
Contrato Predoctoral
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Jennifer Redondo Antón
Contrato Predoctoral
List of staff
Additional Information
This group, together with the CNM Serology Laboratory (LS), houses the National Reference Laboratories for Rabies (RD 1940/2004) and Measles and Rubella (National Elimination Plan) that are integrated into the corresponding European networks. It has 10 self-developed techniques in its service portfolio (2 accredited by ENAC and 3 by the WHO). In addition, it attends to three CNM microbiological surveillance programs (measles and rubella, mumps and rabies). It is integrated into a CIBERESP group of which Juan E. Echevarría is head and in which other CNM researchers participate.
Research on MMR vaccine diseases is currently financed through an AESI project (PI15CIII/00023) of which Aurora Fernández García is co-PI and in which the LS, the CNE, the CAM (LRSP and the Epidemiology Service) and a network of primary care pediatricians participate. of the CAM.
Research on lisaviruses and other viruses associated with bats is currently funded through the VIROBAT-4 project (MINECO, SAF 2017-89355-P) of which Juan E. Echevarría is PI and in which the CNM Respiratory Viruses Laboratory, the Doñana Biological Station (CSIC) and the University of Alcalá de Henares participate.
This group, together with the CNM Serology Laboratory (LS), houses the National Reference Laboratories for Rabies (RD 1940/2004) and Measles and Rubella (National Elimination Plan) that are integrated into the corresponding European networks. It has 10 self-developed techniques in its service portfolio (2 accredited by ENAC and 3 by the WHO). In addition, it attends to three CNM microbiological surveillance programs (measles and rubella, mumps and rabies). It is integrated into a CIBERESP group of which Juan E. Echevarría is head and in which other CNM researchers participate.
Research on MMR vaccine diseases is currently financed through an AESI project (PI15CIII/00023) of which Aurora Fernández García is co-PI and in which the LS, the CNE, the CAM (LRSP and the Epidemiology Service) and a network of primary care pediatricians participate. of the CAM.
Research on lisaviruses and other viruses associated with bats is currently funded through the VIROBAT-4 project (MINECO, SAF 2017-89355-P) of which Juan E. Echevarría is PI and in which the CNM Respiratory Viruses Laboratory, the Doñana Biological Station (CSIC) and the University of Alcalá de Henares participate.