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Investigation

Reference and Research on Helminths

Research Lines

Content with Investigacion Hepatitis .

Hepatitis

  1. Diseño de métodos diagnósticos para el estudio de los virus de las hepatitis (VH) A, B, C, D, E: Diseñamos sistemas de PCR para su detección y caracterización.
  2. Evaluación de métodos diagnósticos de los VH. Colaboramos con empresas para estudios de sensibilidad y especificidad de equipos diagnósticos.
  3.  Estudios de Seroprevalencia de los virus de las hepatitis.
  4.  Epidemiología genómica de genomas completos de VHA, VHB, VHC, VHD y VHE en colaboración con el ECDC. Estudios de trazabilidad del VHE.
  5. Caracterización molecular de virus de las hepatitis mediante secuenciación masiva:               a) VHB: mutantes de escape HBsAg (prevalencia y efectos en la detección del HBsAg). Estudio de mutaciones en epítopos de estimulación inmune y mutaciones asociadas a evolución clínica desfavorable.
    1. b) VHC: resistencias a los antivirales de acción directa. Análisis molecular de subtipos poco frecuentes.
      c) Estudios filogenéticos del VHD.
       d) Análisis genómico del VHE.
       e) Investigación etiológica de hepatitis no filiadas mediante estudios de metagenómica.

Research projects

Content with Investigacion Hepatitis .

1.    Proyecto CIBEREPS 2022. Microbiological and genomic investigation of hepatitis in children by metagenomic approach in case and control subjects (IP: Ana Avellón).
2023-2024. En colaboración con el Hospital San Joan de Deu de Barcelona.

2.    MPY 501-19: Tracking hepatitis E virus infection by means of epidemiological research and whole genome sequencing. Project TrazHE. (IP: Ana Avellón). 2020-2024.

3.    Proyecto CIBEREPS 2021 Metagenomic sequencing to identify viral aetiologies in undiagnosed paediatric cases of meningitis and encephalitis (IP: D. Tarragó). 2021-2022.

4.    MPY 383/19 (PEJ2018-004446-A). Ayudas para la promoción de empleo joven e implantación de la garantía juvenil en I+D+I. análisis de la complejidad de secuencias de los virus de la hepatitis A, B, C; D y E (VHA, VHB, VHC, VHD y VHE) mediante técnicas de secuenciación masiva. (IP: Ana Avellón). 2020-2021.

5.    MPY 1285/16 Movilidad "Salvador de Madariaga" programa estatal de promoción de talento y su empleabilidad. (IP: Ana Avellón). 2016.​

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Publications

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High susceptibility to zoliflodacin and conserved target (GyrB) for zoliflodacin among 1209 consecutive clinical Neisseria gonorrhoeae isolates from 25 European countries, 2018.

Unemo M, Ahlstrand J, Sánchez-Busó L, Day M, Aanensen D, Golparian D, Jacobsson S, Cole MJ, Torreblanca RA, Ásmundsdóttir LR, Balla E, De Baetselier I, Bercot B, Carannante A, Caugant D, Borrego MJ, Buder S, Cassar R, Cole M, Dam A, Eder C, Hoffmann S, Hunjak B, Jeverica S, Kirjavainen V, Maikanti-Charalambous P, Miriagou V, Mlynarczyk-Bonikowska B, Pakarna G, Patterson L, Pavlik P, Perrin M, Shepherd J, Stefanelli P, Unemo M, Jelena V, Zákoucká H. J Antimicrob Chemother. 2021 Feb 10:dkab024

PUBMED DOI

Molecular characterization of invasive serogroup B Neisseria meningitidis isolates from Spain during 2015-2018: Evolution of the vaccine antigen factor H binding protein (FHbp)

Abad R, García-Amil C, Navarro C, Martín E, Martín-Díaz A, Vázquez JA. J Infect. 2021 Apr;82(4):37-44

PUBMED DOI

Meningococcal Serogroup B Disease in Vaccinated Children

Soler-Garcia A, Fernández de Sevilla M, Abad R, Esteva C, Alsina L, Vázquez J, Muñoz-Almagro C, Noguera-Julian A. J Pediatric Infect Dis Soc. 2020 Sep 17;9(4):454-459

PUBMED DOI

Distribution of DNA gyrase cleavage sites across the Streptococcus pneumoniae genome: relation to transcription and methylation at GATC sites

Ferrándiz MJ, Hernández P, de la Campa AG. Nucleic Acids Res. 2025; 53(21):gkaf1183.

PUBMED DOI

First Insight into the Genome Sequences of Two Linezolid-Resistant Nocardia farcinica Strains Isolated from Patients with Cystic Fibrosis

2: Valdezate S, Monzón S, Garrido N, Zaballos A, Medina-Pascual MJ, Azcona-Gutiérrez JM, Vilar B, Cuesta I. First Insight into the Genome Sequences of Two Linezolid-Resistant Nocardia farcinica Strains Isolated from Patients with Cystic Fibrosis. Genome Announc. 2017 Nov 16;5(46).

PUBMED DOI

Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens.

3: Martínez I, Oliveros JC, Cuesta I, de la Barrera J, Ausina V, Casals C, de Lorenzo A, García E, García-Fojeda B, Garmendia J, González-Nicolau M, Lacoma A, Menéndez M, Moranta D, Nieto A, Ortín J, Pérez-González A, Prat C, Ramos-Sevillano E, Regueiro V, Rodriguez-Frandsen A, Solís D, Yuste J, Bengoechea JA, Melero JA. Apoptosis, Toll-like, RIG-I-like and NOD-like Receptors Are Pathways Jointly Induced by Diverse Respiratory Bacterial and Viral Pathogens. Front Microbiol. 2017 Mar 1;8:276

PUBMED DOI

Molecular identification, antifungal resistance and virulence of Cryptococcus neoformans and Cryptococcus deneoformans isolated in Seville, Spain

Gago S, Serrano C, Alastruey-Izquierdo A, Cuesta I, Martín-Mazuelos E, Aller AI, Gómez-López A, Mellado E. Molecular identification, antifungal resistance and virulence of Cryptococcus neoformans and Cryptococcus deneoformans isolated in Seville, Spain. Mycoses. 2017 Jan;60(1):40-50

PUBMED DOI

High-Quality Draft Genome Sequence of Babesia divergens, the Etiological Agent of Cattle and Human Babesiosis

7: Cuesta I, González LM, Estrada K, Grande R, Zaballos A, Lobo CA, Barrera J, Sanchez-Flores A, Montero E. High-Quality Draft Genome Sequence of Babesia divergens, the Etiological Agent of Cattle and Human Babesiosis. Genome Announc. 2014 Nov 13;2(6).

PUBMED DOI

Content with Investigacion Hepatitis .

List of staff

Additional Information

The research group that makes up the Helminth Reference and Research Laboratory (RIHE) of the CNM-ISCIII works on different aspects of helminth immunobiology, taking advantage of recombinant DNA approaches, omics sciences, bioinformatics tools and biochemical assays. The research is basically oriented towards:

  1.     The biochemical and molecular characterization of parasitic antigens of interest.
  2.     The analysis of the immune response produced in the host against these antigens and the molecular mechanisms of   these diseases.
  3.     To the development and improvement of diagnostic systems.
  4.     The definition of helminth allergenic candidates.
  5.     The design of possible vaccines and participation in helminthosis control and surveillance strategies.
  6.     Search for antiparasitic drugs.
  7.     Research into new therapeutic alternatives for autoimmune diseases using helminth molecules.

The group works on helminthosis projects caused by species of Taenia spp., Fasciola spp., Trichinella spp., Filarias, O. volvulus, Anisakis spp., Ancylostoma spp., Opisthorchis spp., Schistosoma spp. and with experimental models such as Nippostrongylus brasiliensis and Trichuris muris, among others.

The research group that makes up the Helminth Reference and Research Laboratory (RIHE) of the CNM-ISCIII works on different aspects of helminth immunobiology, taking advantage of recombinant DNA approaches, omics sciences, bioinformatics tools and biochemical assays. The research is basically oriented towards:

  1.     The biochemical and molecular characterization of parasitic antigens of interest.
  2.     The analysis of the immune response produced in the host against these antigens and the molecular mechanisms of   these diseases.
  3.     To the development and improvement of diagnostic systems.
  4.     The definition of helminth allergenic candidates.
  5.     The design of possible vaccines and participation in helminthosis control and surveillance strategies.
  6.     Search for antiparasitic drugs.
  7.     Research into new therapeutic alternatives for autoimmune diseases using helminth molecules.

The group works on helminthosis projects caused by species of Taenia spp., Fasciola spp., Trichinella spp., Filarias, O. volvulus, Anisakis spp., Ancylostoma spp., Opisthorchis spp., Schistosoma spp. and with experimental models such as Nippostrongylus brasiliensis and Trichuris muris, among others.

Content with Investigacion Hepatitis .