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Investigation

Reference and Research on Helminths

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Content with Investigacion Referencia e Investigación en Helmintos .

Referencia e Investigación en Helmintos

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Research projects

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PROYECTOS VIGENTES

Título del proyecto: "Vesículas extracelulares y otras moléculas de parásitos para el tratamiento de la enfermedad inflamatoria intestinal: PARATREAT-IBD"

Referencia: Proyecto PID2022-137661OB-I00 (MPY 341/23) financiado por MCIN/AEI /10.13039/501100011033/ y por FEDER Una manera de hacer Europa
Fecha Inicio:    01/12/2023
Fecha Fin:    31/08/2026
Financiación: 162.500 Euros
Investigador principal: Javier Sotillo
Agencia Financiadora: Agencia Estatal de Investigación. MICINN.


 

Título del proyecto: "Desarrollo de nuevos métodos diagnósticos y de seguimiento de la infección por schistosoma haematobium"

Referencia: PI23CIII00034 / MPY 386/23
Fecha Inicio:    01/01/2024
Fecha Fin:    31/12/2026
Financiación: 131.500 Euros
Investigador principal: Javier Sotillo
Agencia Financiadora: Instituto de Salud Carlos III (ISCIII/AESI)

 

Título del proyecto: "Desarrollo de herramientas para el control de la teniosis / cisticercosis en zonas endémicas y vigilancia de las helmintosis humanas emergentes en España"

Referencia: PI22CIII/00010
Fecha Inicio: 01/01/2023
Fecha Fin: 31/12/2025
Financiación: 80.000 Euros
Investigador principal: María Jesús Perteguer
Agencia Financiadora: Instituto de Salud Carlos III (ISCIII/AESI)

 

 

PROYECTOS PASADOS

Título del proyecto: "PERITAS: Molecular epidemiological studies on pathways of transmission and longlasting capacity building to prevent cystic echinococcosis infection."
Coordinador: Adriano Casulli. IP of ISCIII: Maria J. Perteguer.
Entidad financiadora: EULAC Health JOINT CALL on Research and Innovation 016-2017
Periodo: 01/03/2019-31/12/2022.
Cuantía total: 1.083.580 €.

Título del proyecto: "Producción de antígenos y controles positivos recombinantes para el desarrollo y la estandarización de nuevos ensayos serológicos aplicados al diagnóstico y control de helmintosis olvidadas. "
Investigador principal: María Jesús Perteguer.
Entidad financiadora: ISCIII-AESI. Instituto de Salud Carlos III
Periodo: 02/11/2018 - 31/06/2022.
Cuantía total: 78.050 €.

Título del proyecto: "Diagnóstico serológico diferencial de helmintiasis asociadas a eosinofilia: desarrollo de ensayos multianalito (xMAP) con antígenos recombinantes de especies de interés clínico"
Investigador principal: María Jesús Perteguer.
Entidad financiadora: ISCIII-AESI. Instituto de Salud Carlos III
Periodo: 01/01/2015 - 31/12/2018 .
Cuantía total: 91.000 €.

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Publications

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Sequence analysis of in vivo-expressed HIV-1 spliced RNAs reveals the usage of new and unusual splice sites by viruses of different subtypes

Vega Y, Delgado E, de la Barrera J, Carrera C, Zaballos Á, Cuesta I, Mariño A, Ocampo A, Miralles C, Pérez-Castro S, Álvarez H, López-Miragaya I, García-Bodas E, Díez-Fuertes F, Thomson MM. Sequence analysis of in vivo-expressed HIV-1 spliced RNAs reveals the usage of new and unusual splice sites by viruses of different subtypes. PLoS One. 2016; 11:e0158525.

PUBMED DOI

HIV-1 genetic diversity in recently diagnosed infections in Moscow: predominance of AFSU, frequent branching in clusters, and circulation of the Iberian subtype G variant.

Karamov E, Epremyan K, Siniavin A, Zhernov Y, Cuevas MT, Delgado E, Sánchez-Martínez M, Carrera C, Kornilaeva G, Turgiev A, Bacqué J, Pérez-Álvarez L, Thomson MM. HIV-1 genetic diversity in recently diagnosed infections in Moscow: predominance of AFSU, frequent branching in clusters, and circulation of the Iberian subtype G variant. AIDS Res Hum Retroviruses. 2018; 34:629-634.

PUBMED DOI

Bayesian phylogeographic analyses clarify the origin of the HIV-1 subtype A variant circulating in former Soviet Union's countries.

Díez-Fuertes F, Cabello M, Thomson MM. Bayesian phylogeographic analyses clarify the origin of the HIV-1 subtype A variant circulating in former Soviet Union's countries. Infect Genet Evol. 2015; 33:197-205.

PUBMED DOI

Alcazar-Fuoli L, Clavaud C, Lamarre C, Aimanianda V, Seidl-Seiboth V, Mellado E, Latgé JP. Functional analysis of the fungal/plant class chitinase family in Aspergillus fumigatus.

Alcazar-Fuoli L, Clavaud C, Lamarre C, Aimanianda V, Seidl-Seiboth V, Mellado E, Latgé JP. Functional analysis of the fungal/plant class chitinase family in Aspergillus fumigatus. Fungal Genet Biol. 2011 Apr;48(4):418-29. doi: 10.1016/j.fgb.2010.12.007. Epub 2010 Dec 22. PMID: 21184840.

PUBMED DOI

Impact of DARC rs12075 Variants on Liver Fibrosis Progression in Patients with Chronic Hepatitis C: A Retrospective Study.

Jiménez-Sousa MA (AC); Gómez-Moreno AZ; Pineda-Tenor D; et al. (1/9) Impact of DARC rs12075 Variants on Liver Fibrosis Progression in Patients with Chronic Hepatitis C: A Retrospective Study. Biomolecules 2019; 9(4).​

DBP rs16846876 and rs12512631 polymorphisms are associated with progression to AIDS naïve HIV-infected patients: a retrospective study.

Jiménez-Sousa MA (AC); Jiménez JL; Fernández-Rodríguez A; et al. (1/10). DBP rs16846876 and rs12512631 polymorphisms are associated with progression to AIDS naïve HIV-infected patients: a retrospective study. Journal of Biomedical Science. 2019; 23;26(1):83. doi: 10.1186/s12929-019-0577-y.

TRPM5 rs886277 Polymorphism Predicts Hepatic Fibrosis Progression in Non-Cirrhotic HCV-Infected Patients.Journal of Clinical Medicine.

Resino S; Fernández-Rodríguez A; Pineda-Tenor D; et al; Jiménez-Sousa MA. (11/11). 2021. TRPM5 rs886277 Polymorphism Predicts Hepatic Fibrosis Progression in Non-Cirrhotic HCV-Infected Patients.Journal of Clinical Medicine. 10-3, pp.483. ISSN 2077-0383. https://doi.org/10.3390/jcm10030483.

Plasma metabolomic fingerprint of advanced cirrhosis stages among HIV/HCV-coinfected and HCV-monoinfected patients

Salguero, Sergio; Rojo, David; Berenguer, Juan; et al; Jimenez-Sousa, Maria A. (AC) (15/15). 2020. Plasma metabolomic fingerprint of advanced cirrhosis stages among HIV/HCV-coinfected and HCV-monoinfected patients LIVER INTERNATIONAL. 40-9, pp.2215-2227. ISSN 1478-3223. https://doi.org/10.1111/liv.14580 3

Content with Investigacion Referencia e Investigación en Helmintos .

List of staff

Additional Information

The research group that makes up the Helminth Reference and Research Laboratory (RIHE) of the CNM-ISCIII works on different aspects of helminth immunobiology, taking advantage of recombinant DNA approaches, omics sciences, bioinformatics tools and biochemical assays. The research is basically oriented towards:

  1.     The biochemical and molecular characterization of parasitic antigens of interest.
  2.     The analysis of the immune response produced in the host against these antigens and the molecular mechanisms of   these diseases.
  3.     To the development and improvement of diagnostic systems.
  4.     The definition of helminth allergenic candidates.
  5.     The design of possible vaccines and participation in helminthosis control and surveillance strategies.
  6.     Search for antiparasitic drugs.
  7.     Research into new therapeutic alternatives for autoimmune diseases using helminth molecules.

The group works on helminthosis projects caused by species of Taenia spp., Fasciola spp., Trichinella spp., Filarias, O. volvulus, Anisakis spp., Ancylostoma spp., Opisthorchis spp., Schistosoma spp. and with experimental models such as Nippostrongylus brasiliensis and Trichuris muris, among others.

The research group that makes up the Helminth Reference and Research Laboratory (RIHE) of the CNM-ISCIII works on different aspects of helminth immunobiology, taking advantage of recombinant DNA approaches, omics sciences, bioinformatics tools and biochemical assays. The research is basically oriented towards:

  1.     The biochemical and molecular characterization of parasitic antigens of interest.
  2.     The analysis of the immune response produced in the host against these antigens and the molecular mechanisms of   these diseases.
  3.     To the development and improvement of diagnostic systems.
  4.     The definition of helminth allergenic candidates.
  5.     The design of possible vaccines and participation in helminthosis control and surveillance strategies.
  6.     Search for antiparasitic drugs.
  7.     Research into new therapeutic alternatives for autoimmune diseases using helminth molecules.

The group works on helminthosis projects caused by species of Taenia spp., Fasciola spp., Trichinella spp., Filarias, O. volvulus, Anisakis spp., Ancylostoma spp., Opisthorchis spp., Schistosoma spp. and with experimental models such as Nippostrongylus brasiliensis and Trichuris muris, among others.

Content with Investigacion Referencia e Investigación en Helmintos .