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Investigación

Water-borne and Food-borne Bacterial Diseases

Líneas de investigación

Content with Investigacion Infecciones Bacterianas Transmitidas por Agua y Alimentos .

Legionella

Desde su creación hasta la actualidad, La Unidad de Legionella tiene como principal función dar apoyo científico-técnico a la Administración General del Estado, a las Comunidades Autónomas y al Sistema Nacional de Salud en el campo de la prevención y control de la legionelosis, así como llevar a cabo investigaciones científicas en el contexto de la legionelosis. Además, la Unidad de Legionella también actúa como Laboratorio de Referencia de España frente al European Centre for Disease Prevention and Control (ECDC), siendo miembro de la red europea de vigilancia de la legionelosis, “European Legionnaires’ Disease Surveillance Network (ELDSNet). Finalmente, la unidad también realiza una actividad docente, participando en cursos de formación especializada, así como en Máster Universitarios.

 

Principales líneas de investigación

Vigilancia microbiológica

Búsqueda de marcadores moleculares con capacidad de predecir el riesgo de una instalación de provocar legionelosis. Factores de virulencia de Legionella spp.

Estudio de la capacidad formadora de biofilms de Legionella spp. Colonización y dispersión.

Búsqueda de marcadores fenotípicos capaces de discriminar especies del Género Legionella; grupos y subgrupos de Legionella pneumophila.

Diferentes estructuras de biofilms en función de la cepa formadora de Legionella pneumophila. En verde la biomasa bacteriana, en rojo el exopolisacárido de la matriz extracelular.

Apoyo al Sistema Nacional de Salud de la Unidad de Legionella

 

La Unidad de Legionella tambien desarrolla actividades con el fin de proporcionar asistencia al sistema nacional de salud a traves de la oferta disponible en la cartera de servicios del CNM, así como a través de programas de vigilancia microbiológica.

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Publicaciones destacadas

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Increase in isolation of Burkholderia contaminans from Spanish patients with cystic fibrosis.

Medina-Pascual MJ, Valdezate S, Carrasco G, Villalón P, Garrido N, Saéz-Nieto JA. (2015) Increase in isolation of Burkholderia contaminans from Spanish patients with cystic fibrosis. Clin Microbiol Infect. ;21(2):150-6

PUBMED DOI

CD45 expression discriminates waves of embryonic megakaryocytes in the mouse.

Cortegano, I., Serrano, N., Ruiz, C., Rodríguez, M., Prado, C., Alía, M., Hidalgo, A., Cano, E., de Andrés B. and Gaspar, ML. 2018. Haematologica, 104(9):1853-1865

PUBMED DOI

Upregulation of the PatAB transporter confers fluoroquinolone resistance to Streptococcus pseudopneumoniae

Alvarado M, Martín-Galiano AJ, Ferrándiz MJ, Zaballos A, de la Campa AG. Front Microbiol. 8:2074 (2017).

PUBMED DOI

Broadly cross-neutralizing antibodies in HIV-1 patients with undetectable viremia

Medina-Ramirez M, Sanchez-Merino V, Sanchez-Palomino S, Merino-Mansilla A, Ferreira CB, Perez I, Gonzalez N, Alvarez A, Alcocer-Gonzalez JM, Garcia F, Gatell JM, Alcami J, Yuste E; J Virol. 2011 Jun;85(12):5804-13.

PUBMED DOI

Multi-resistance to non-azole fungicides in Aspergillus fumigatus TR34/L98H azole resistant isolates

Gonzalez-Jimenez I, Garcia-Rubio R, Monzon S, Lucio J, Cuesta I, and Mellado E. Antimicrob Agents Chemother. 17;65(9):e0064221

PUBMED DOI

Resistance gene pool to co-trimoxazole in non-susceptible Nocardia strains

Valdezate S, Garrido N, Carrasco G, Villalón P, Medina-Pascual MJ, Saéz-Nieto JA. (2015). Resistance gene pool to co-trimoxazole in non-susceptible Nocardia strains. Front Microbiol. 2015 Apr 28;6:376

PUBMED DOI

Podocytes as new cellular targets of hemoglobin toxicity in massive intravascular hemolysis.

Rubio-Navarro A, Sanchez-Niño MD, Guerrero-Hue M, García-Caballero C, Gutiérrez E, Yuste C, Sevillano A, Praga M, Egea J, Román E, Cannata P, Ortega R, Cortegano I, de Andrés B, Gaspar ML, Cadenas S, Ortiz A, Egido J, Moreno JA. Podocytes as new cellular targets of hemoglobin toxicity in massive intravascular hemolysis. 2018. J.Pathol. 244(3):296-310.

PUBMED DOI

A novel typing method for Streptococcus pneumoniae using selected surface proteins

Domenech A, Moreno J, Ardanuy C, Liñares J, de la Campa AG, Martin-Galiano AJ. Front Microbiol. 2016; 31;7:420.

PUBMED DOI

Vector-mediated gene transfer engenders long-lived neutralizing activity and protection against SIV infection in monkeys

Johnson PR, Schnepp BC, Zhang J, Connell MJ, Greene SM, Yuste E, Desrosiers RC, Clark KR; Nat Med. 2009 Aug;15(8):901-6

PUBMED DOI

Genomic Background and Phylogeny of cfiA-Positive Bacteroides fragilis Strains Resistant to Meropenem-EDTA

Medina-Pascual MJ, Valdezate S, Carrasco G, Villalón P, Garrido N, Saéz-Nieto JA. (2015) Increase in isolation of Burkholderia contaminans from Spanish patients with cystic fibrosis. Clin Microbiol Infect. ;21(2):150-6.

PUBMED DOI

Spatially-restricted JAG1-Notch signaling in the human thymus provides permissive microenvironments for dendritic cell development.

Martín Gayo, E., González-García, S., García-León, M., Murcia-Ceballos, A., Alcain, J., García-Peydró, M., Allende, L., de Andrés, B., Gaspar, ML. and Toribio, ML. J.Exp.Med. (2017) 214:3361-3379

PUBMED DOI

An increase in negative supercoiling in bacteria reveals topology-reacting gene clusters and a homeostatic response mediated by the DNA topoisomerase I gene

Ferrándiz MJ, Martín-Galiano AJ, Arnanz C, Camacho-Soguero I, Tirado-Vélez JM, de la Campa AG. 2016. Nucl Acids Res. 44:7292-7303 (2016).

PUBMED DOI

Identification and characterization of HIV-1 CD8+ T cell escape variants with impaired fitness

Sanchez-Merino V, Farrow MA, Brewster F, Somasundaran M, Luzuriaga K; J Infect Dis. 2008 Jan 15;197(2):300-8

PUBMED DOI

Epidemiology of the Acinetobacter-derived cephalosporinase, carbapenem-hydrolysing oxacillinase and metallo-beta-lactamase genes, and of common insertion sequences, in epidemic clones of Acinetobacter baumannii from Spain

Villalón P, Valdezate S, Medina-Pascual MJ, Carrasco G, Vindel A, Saez-Nieto JA. Epidemiology of the Acinetobacter-derived cephalosporinase, carbapenem-hydrolysing oxacillinase and metallo-beta-lactamase genes, and of common insertion sequences, in epidemic clones of Acinetobacter baumannii from Spain. J Antimicrob Chemother. 2013;68(3):550-3.

PUBMED DOI

Altered Marginal Zone and innate-like B cells in aged SAMP8 mice with defective IgG1 responses

Cortegano, I., Rodriguez, M., Martin, I., Prado, C., Ruiz, C., Hortigüela, R., Alia, M., Vilar, M., Mira, H., Cano, E., de Andrés, B., and Gaspar, ML. Cell death & disease (2017) 8, e3000

PUBMED DOI

Reactive oxygen species contribute to the bactericidal effects of the fluoroquinolone moxifloxacin in Streptococcus pneumoniae

Ferrándiz MJ, Martín-Galiano AJ, Arnanz C, Zimmerman T, de la Campa AG. Antimicrob Agents Chemother. 60:409-417 (2016).

PUBMED DOI

Glycosylation of gp41 of simian immunodeficiency virus shields epitopes that can be targets for neutralizing antibodies

Yuste E, Bixby J, Lifson J, Sato S, Johnson W, Desrosiers R*. 2008. J Virol 82:12472-86.

PUBMED DOI

The fluoroquinolone levofloxacin triggers the transcriptional activation of iron transport genes that contribute to cell death in Streptococcus pneumoniae.

Ferrándiz MJ, de la Campa AG. Antimicrob Agents Chemother. 58:247-257 (2014)

PUBMED DOI

The formation of titan cells in Cryptococcus neoformans depends on the mouse strain and correlates with induction of Th2-type responses

García-Barbazán, I., Trevijano-Contador, N., Rueda, C., de Andrés, B., Pérez-Tavárez, R., Herrero-Fernández, I., Gaspar ML., and Zaragoza, O. Cellular Microbiology (2015) 18:111-124

PUBMED DOI

Simian immunodeficiency virus engrafted with human immunodeficiency virus type 1 (HIV-1)-specific epitopes: replication, neutralization, and survey of HIV-1-positive plasma

Yuste E, Sanford HB, Carmody J, Bixby J, Little S, Zwick MB, Greenough T, Burton DR, Richman DD, Desrosiers RC, Johnson WE*. 2006. J Virol 80:3030-41.

PUBMED DOI

Content with Investigacion Infecciones Bacterianas Transmitidas por Agua y Alimentos .

List of staff

Información adicional

The Reference and Research Laboratory for Water-borne an Food-borne Bacterial Diseases (LRIEBTAA) is recognized as a national reference laboratory for the zoonotic agents Salmonella, verotoxigenic Escherichia coli, Yersinia., Campylobacter. and Vibrio (RD 1940/2004 of September 27, Order APA/1808/2007 of June 13). In this sense, its main activity is to ensure adequate surveillance of these zoonoses, zoonotic agents and associated antibiotic resistance, as well as proper investigation of outbreaks caused by these microorganisms. In addition, the LRIEBTAA acts as a reference laboratory for Shigella, other diarrheagenic groups of E. coli, Legionella and toxigenic Corynebacterium species. Added to its reference activity is its applied research activity, among which those mentioned above stand out. 

The members of the group carry out an important training activity. Every year, 3-5 students who develop their final Master's or Degree projects, laboratory technicians in training and rotating students of the specialty of Clinical Microbiology from different national origins are welcomed in the laboratory. In addition, it actively participates in the Public Health microbiologist training program funded by the ECDC through its supervision at the national level and coordination/supervision at the international level.

Content with Investigacion Infecciones Bacterianas Transmitidas por Agua y Alimentos .

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