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Investigación

Water-borne and Food-borne Bacterial Diseases

Líneas de investigación

Content with Investigacion Infecciones Bacterianas Transmitidas por Agua y Alimentos .

Legionella

Desde su creación hasta la actualidad, La Unidad de Legionella tiene como principal función dar apoyo científico-técnico a la Administración General del Estado, a las Comunidades Autónomas y al Sistema Nacional de Salud en el campo de la prevención y control de la legionelosis, así como llevar a cabo investigaciones científicas en el contexto de la legionelosis. Además, la Unidad de Legionella también actúa como Laboratorio de Referencia de España frente al European Centre for Disease Prevention and Control (ECDC), siendo miembro de la red europea de vigilancia de la legionelosis, “European Legionnaires’ Disease Surveillance Network (ELDSNet). Finalmente, la unidad también realiza una actividad docente, participando en cursos de formación especializada, así como en Máster Universitarios.

 

Principales líneas de investigación

Vigilancia microbiológica

Búsqueda de marcadores moleculares con capacidad de predecir el riesgo de una instalación de provocar legionelosis. Factores de virulencia de Legionella spp.

Estudio de la capacidad formadora de biofilms de Legionella spp. Colonización y dispersión.

Búsqueda de marcadores fenotípicos capaces de discriminar especies del Género Legionella; grupos y subgrupos de Legionella pneumophila.

Diferentes estructuras de biofilms en función de la cepa formadora de Legionella pneumophila. En verde la biomasa bacteriana, en rojo el exopolisacárido de la matriz extracelular.

Apoyo al Sistema Nacional de Salud de la Unidad de Legionella

 

La Unidad de Legionella tambien desarrolla actividades con el fin de proporcionar asistencia al sistema nacional de salud a traves de la oferta disponible en la cartera de servicios del CNM, así como a través de programas de vigilancia microbiológica.

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Publicaciones destacadas

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HIV screening and retention in care in people who use drugs in Madrid, Spain: a prospective study

Ryan P, Valencia J, Cuevas G; Troya J; Torres-Macho J; Muñoz-Gómez MJ, Muñoz-Rivas N, Canorea I, Vázquez-Morón S (‡), Resino S (‡ *). HIV screening and retention in care in people who use drugs in Madrid, Spain: A prospective study. Infect Dis Poverty. 2021; 10(1): 111. (A; FI= 10.49; D1, Tropical Medicine; JCR 2021). PMID: 34412695. DOI: 10.1186/s40249-021-00894-5.

PUBMED

Obesity-related SNPs and weight gain following first-line antiretroviral therapy.

Berenguer J (*), Jarrín I, Bellón JM, Díez C, Jiménez-Sousa MA, Roca C, González-García J, Dalmau D, Olalla J, Herrero C, Villarroya F, Domingo P, Resino S. Obesity-related SNPs and weight gain following first-line antiretroviral therapy. Clin Inf Dis. 2023; In press. (A; FI= 20.99; D1, Infectious Diseases; JCR 2021).

PUBMED DOI

Mild profile improvement of immune biomarkers in HIV/HCV-coinfected patients who removed hepatitis C after HCV treatment: a prospective study.

García-Broncano P, Medrano LM, Berenguer J, Brochado O, González-García J, Jiménez-Sousa MA, Quereda C, Sanz J, Téllez MJ, Díaz L, Jiménez JL, Muñoz-Fernández MA, Resino S (*). Mild profile improvement of immune biomarkers in HIV/HCV-coinfected patients who removed hepatitis C after HCV treatment: a prospective study. J Infect 2020; 80(1):99-110. (A; FI= 6.07; Q1, Infectious Diseases; JCR 2020). PMID: 31585189. DOI: 10.1016/j.jinf.2019.09.020.

PUBMED

Evaluation of the possible influence of trailing and paradoxical effects on the clinical outcome of patients with candidemia

Rueda C, Puig-Asensio M, Guinea J, Almirante B, Cuenca-Estrella M, Zaragoza O; CANDIPOP Project from GEIH-GEMICOMED (SEIMC) and REIPI. Evaluation of the possible influence of trailing and paradoxical effects on the clinical outcome of patients with candidemia. Clin Microbiol Infect. 2017 Jan;23(1):49.e1-49.e8.

PUBMED DOI

Identification of Off-Patent Drugs That Show Synergism with Amphotericin B or That Present Antifungal Action against Cryptococcus neoformans and Candida spp

Rossi SA, de Oliveira HC, Agreda-Mellon D, Lucio J, Mendes-Giannini MJS, García-Cambero JP, Zaragoza O. Identification of Off-Patent Drugs That Show Synergism with Amphotericin B or That Present Antifungal Action against Cryptococcus neoformans and Candida spp. Antimicrob Agents Chemother. 2020 Mar 24;64(4):e01921-19. PMCID: PMC7179310.

PUBMED DOI

Paradoxical Growth of Candida albicans in the Presence of Caspofungin Is Associated with Multiple Cell Wall Rearrangements and Decreased Virulence

Rueda C, Cuenca-Estrella M, Zaragoza O. Paradoxical growth of Candida albicans in the presence of caspofungin is associated with multiple cell wall rearrangements and decreased virulence. Antimicrob Agents Chemother. 2014;58(2):1071-83. PMCID: PMC3910852.

PUBMED DOI

HCV cure with direct-acting antivirals improves liver and immunological markers in HIV/HCV-coinfected patients.

Brochado-Kith O, Martínez I, Berenguer J, González-García J, Salgüero S, Sepúlveda-Crespo D, Díez C, Hontañón V, Ibañez-Samaniego L, Pérez-Latorre L, Fernández-Rodríguez A (‡), Jiménez-Sousa MA (‡), Resino S (‡ *). HCV cure with direct-acting antivirals improves liver and immunological markers in HIV/HCV-coinfected patients. Front immunol. 2021; 12:723196. (A; FI= 8.79; Q1, Immunology; JCR 2021). PMID: 34497613. DOI: 10.3389/fimmu.2021.723196.

PUBMED

Cryptococcus neoformans induces antimicrobial responses and behaves as a facultative intracellular pathogen in the non mammalian model Galleria mellonella

Trevijano-Contador N, Herrero-Fernández I, García-Barbazán I, Scorzoni L, Rueda C, Rossi SA, García-Rodas R, Zaragoza O. Cryptococcus neoformans induces antimicrobial responses and behaves as a facultative intracellular pathogen in the non mammalian model Galleria mellonella. Virulence. 2015;6(1):66-74. PMCID: PMC4603429.

PUBMED DOI

The formation of titan cells in Cryptococcus neoformans depends on the mouse strain and correlates with induction of Th2-type responses

García-Barbazán I, Trevijano-Contador N, Rueda C, de Andrés B, Pérez-Tavárez R, Herrero-Fernández I, Gaspar ML, Zaragoza O. The formation of titan cells in Cryptococcus neoformans depends on the mouse strain and correlates with induction of Th2-type responses. Cell Microbiol. 2016 Jan;18(1):111-24.

PUBMED DOI

Frequency of hepatitis B virus 'a' determinant variant in unselected Spanish chronic carriers.

• Avellón A, Echevarria JM. Frequency of hepatitis B virus 'a' determinant variant in unselected Spanish chronic carriers. J Med Virol. 2006 Jan;78(1):24-36.

PUBMED DOI

Prevalence and undiagnosed fraction of hepatitis C infection in 2018 in Spain: results from a national population-based survey.

• Estirado Gómez A, Justo-Gil S, Limia A, Avellón A, Arce-Arnáez A, González-Rubio R, Diaz A, Del Amo J; Prevalence and undiagnosed fraction of hepatitis C infection in 2018 in Spain: results from a national population-based survey. Sci Rep. 2018 Jan 30;8(1):1858.

PUBMED DOI

Comparative Analysis of Aspergillus fumigatus Strains: The Reference Genome as a Matter of Concern.

Buitrago MJ, Martín-Gómez T. Timely Diagnosis of Histoplasmosis in Non-endemic Countries: A Laboratory Challenge. Front Microbiol. 2020 Mar 24; 11:467. doi: 10.3389/fmicb.2020.00467. eCollection 2020. PMID: 32269555.

PUBMED DOI

Identification of Novel Short C-Terminal Transcripts of Human SERPINA1 Gene.

Matamala N, Aggarwal N, Iadarola P, Fumagalli M, Gomez-Mariano G, Lara B, Martinez MT, Cuesta I, Stolk J, Janciauskiene S, Martinez-Delgado B. Identification of Novel Short C-Terminal Transcripts of Human SERPINA1 Gene. PLoS One. 2017 Jan 20;12(1):e0170533.

PUBMED DOI

Sequence Analysis of In Vivo-Expressed HIV-1 Spliced RNAs Reveals the Usage of New and Unusual Splice Sites by Viruses of Different Subtypes.

Vega Y, Delgado E, de la Barrera J, Carrera C, Zaballos Á, Cuesta I, Mariño A, Ocampo A, Miralles C, Pérez-Castro S, Álvarez H, López-Miragaya I, García-Bodas E, Díez-Fuertes F, Thomson MM. Sequence Analysis of In Vivo-Expressed HIV-1 Spliced RNAs Reveals the Usage of New and Unusual Splice Sites by Viruses of Different Subtypes. PLoS One. 2016 Jun 29;11(6):e0158525.

PUBMED DOI

Y155H amino acid substitution in influenza A(H1N1)pdm09 viruses does not confer a phenotype of reduced susceptibility to neuraminidase inhibitors

Perez-Sautu U, Pozo F, Cuesta I, Monzon S, Calderon A, Gonzalez M, Molinero M, Lopez-Miragaya I, Rey S, Cañizares A, Rodriguez G, Gonzalez-Velasco C, Lackenby A, Casas I. Y155H amino acid substitution in influenza A(H1N1)pdm09 viruses does not confer a phenotype of reduced susceptibility to neuraminidase inhibitors. Euro Surveill. 2014 Jul 10;19(27):14-20.

PUBMED DOI

Comparison of two highly discriminatory typing methods to analyze Aspergillus fumigatus azole resistance

Garcia-Rubio R, Escribano P, Gomez A, Guinea J, and Mellado E. Comparison of two highly discriminatory typing methods to analyze Aspergillus fumigatus azole resistance. Frontiers in Microbiology 2018. Jul 20;9:1626.

PUBMED DOI

Evaluation of the possible influence of trailing and paradoxical effects on the clinical outcome of patients with candidemia.

Rueda C, Puig-Asensio M, Guinea J, Almirante B, Cuenca-Estrella M, Zaragoza O. Evaluation of the possible influence of trailing and paradoxical effects on the clinical outcome of patients with candidemia. CANDIPOP Project from GEIH-GEMICOMED (SEIMC) and REIPI. Clin Microbiol Infect. 2017 Jan; 23(1):49.e1-49.e8.

PUBMED DOI

Development and Validation of a High-Resolution Melting Assay To Detect Azole Resistance in Aspergillus fumigatus.

Bernal-Martínez L, Gil H, Rivero-Menéndez O, Gago S, Cuenca-Estrella M, Mellado E, Alastruey-Izquierdo A. Development and Validation of a High-Resolution Melting Assay To Detect Azole Resistance in Aspergillus fumigatus. Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01083-17.

PUBMED DOI

Cervicofacial lymphadenitis due Mycobacterium mantenii: rapid and reliable identification by MALDI-TOF MS.

Nebreda T, Andres AG, Fuentes S, Calleja R, Jimenez MS. Cervicofacial lymphadenitis due Mycobacterium mantenii: rapid and reliable identification by MALDI-TOF MS. New Microbes and New Infections .2018. March 22:1-3.

PUBMED DOI

In-depth analysis of the genome sequence of a clinical, extensively drug-resistant Mycobacterium bovis strain.

Sagasta S, Millan-Lou MI, Jiménez MS, Martin C, Samper S. In-depth analysis of the genome sequence of a clinical, extensively drug-resistant Mycobacterium bovis strain. Tuberculosis. 2016. Sep. 100:46-52.

PUBMED DOI

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List of staff

Información adicional

The Reference and Research Laboratory for Water-borne an Food-borne Bacterial Diseases (LRIEBTAA) is recognized as a national reference laboratory for the zoonotic agents Salmonella, verotoxigenic Escherichia coli, Yersinia., Campylobacter. and Vibrio (RD 1940/2004 of September 27, Order APA/1808/2007 of June 13). In this sense, its main activity is to ensure adequate surveillance of these zoonoses, zoonotic agents and associated antibiotic resistance, as well as proper investigation of outbreaks caused by these microorganisms. In addition, the LRIEBTAA acts as a reference laboratory for Shigella, other diarrheagenic groups of E. coli, Legionella and toxigenic Corynebacterium species. Added to its reference activity is its applied research activity, among which those mentioned above stand out. 

The members of the group carry out an important training activity. Every year, 3-5 students who develop their final Master's or Degree projects, laboratory technicians in training and rotating students of the specialty of Clinical Microbiology from different national origins are welcomed in the laboratory. In addition, it actively participates in the Public Health microbiologist training program funded by the ECDC through its supervision at the national level and coordination/supervision at the international level.

Content with Investigacion Infecciones Bacterianas Transmitidas por Agua y Alimentos .

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