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HIV Biology and Variability
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Neumococos
Vigilancia epidemiológica de los serotipos y genotipos que causan enfermedad neumocócica invasiva (ENI) en España. Caracterización molecular de factores de virulencia de neumococo. Identificación y caracterización de proteínas de neumococo candidatas a vacuna. Evaluación de mecanismos de evasión de la respuesta inmune en Streptococcus pneumoniae. Impacto de los biofilms bacterianos en la persistencia del tracto respiratorio. Mecanismos de cronicidad de aislados clínicos de neumococo en pacientes con enfermedad pulmonar obstructiva crónica.
Publicaciones destacadas
Outbreak of brainstem encephalitis associated with enterovirus-A71 in Catalonia, Spain (2016): a clinical observational study in a children’s reference centre in Catalonia
6. D Casas-Alba, M de Sevilla, A Valero-Rello, C Fortuny, JJ Garcia, C Ortez, J Muchart, T Armangue, I Jordan, C Luaces-Cubells, I Barrabeig, R González-Sanz, M Cabrerizo, C Munoz-Almagro, C Launes. Outbreak of brainstem encephalitis associated with enterovirus-A71 in Catalonia, Spain (2016): a clinical observational study in a children’s reference centre in Catalonia. Clin Microbiol Infect 23: 874-881 (2017)
PUBMED DOIMolecular epidemiology of enterovirus and parechovirus infections according to patient age over a 4-year period in Spain.
7. M Cabrerizo*, M Díaz-Cerio, C Muñoz-Almagro, N Rabella, D Tarragó, MP Romero, MJ Pena, C Calvo, S Rey-Cao, A Moreno-Docón, I Martínez-Rienda, A Otero, G Trallero. Molecular epidemiology of enterovirus and parechovirus infections according to patient age over a 4-year period in Spain. J Med Virol 89: 435-442 (2017).
PUBMED DOIMolecular epidemiology of enterovirus 71, coxsackievirus A16 and A6 associated with hand, foot and mouth disease in Spain
9. M Cabrerizo*, D Tarragó, C Muñóz-Almagro, E del Amo, M Domínguez-Gil, JM Eiros, I López-Miragaya, C Pérez, J Reina, A Otero, I González, JE Echevarría, G Trallero. Molecular epidemiology of enterovirus 71, coxsackievirus A16 and A6 associated with hand, foot and mouth diease in Spain. Clin Microbiol Infect; 20: O150–O156 (2014).
PUBMED DOIImpact of pretransplant CMV-specific T-cell immune response in the control of CMV infection after solid organ transplantation: a prospective cohort study. Clin Microbiol Infect.
Molina-Ortega A, Martín-Gandul C, Mena-Romo JD, Rodríguez-Hernández MJ, Suñer M, Bernal C, Sánchez M, Sánchez-Céspedes J, Pérez Romero P*, Cordero E. Impact of pretransplant CMV-specific T-cell immune response in the control of CMV infection after solid organ transplantation: a prospective cohort study. Clin Microbiol Infect. 2019 Jun;25(6):753-758.
PUBMED DOIKinetic of the CMV-specific T-cell immune response and CMV infection in CMV-seropositive kidney transplant recipients receiving rabbit anti-thymocyte globulin induction therapy: A pilot study.
Martín-Gandul C, Pérez-Romero P*, Mena-Romo D, Molina-Ortega A, González-Roncero FM, Suñer M, Bernal G, Cordero E; Spanish Network for Research in Infectious Diseases (REIPI). Kinetic of the CMV-specific T-cell immune response and CMV infection in CMV-seropositive kidney transplant recipients receiving rabbit anti-thymocyte globulin induction therapy: A pilot study. Transpl Infect Dis. 2018 Jun;20(3):e12883.
PUBMED DOICMV-specific T-cell immunity in solid organ transplant recipients at low risk of CMV infection. Chronology and applicability in preemptive therapy.
Mena-Romo JD, Pérez Romero P*, Martín-Gandul C, Gentil MÁ, Suárez-Artacho G, Lage E, Sánchez M, Cordero E. CMV-specific T-cell immunity in solid organ transplant recipients at low risk of CMV infection. Chronology and applicability in preemptive therapy. J Infect. 2017 Oct;75(4):336-345.
PUBMED DOITwo Doses of Inactivated Influenza Vaccine Improve Immune Response in Solid Organ Transplant Recipients: Results of TRANSGRIPE 1-2, a Randomized Controlled Clinical Trial.
Cordero E, Roca-Oporto C, Bulnes-Ramos A, Aydillo T, Gavaldà J, Moreno A, Torre-Cisneros J, Montejo JM, Fortun J, Muñoz P, Sabé N, Fariñas MC, Blanes-Julia M, López-Medrano F, Suárez-Benjumea A, Martinez-Atienza J, Rosso-Fernández C, Pérez-Romero P*. Two Doses of Inactivated Influenza Vaccine Improve Immune Response in Solid Organ Transplant Recipients: Results of TRANSGRIPE 1-2, a Randomized Controlled Clinical Trial. Clin Infect Dis. 2017 Apr 1;64(7):829-838.
PUBMED DOIApplying lessons learned from cytomegalovirus infection in transplant patients to vaccine design.
Blanco-Lobo P, Bulnes-Ramos Á, McConnell MJ, Navarro D, Pérez-Romero P*. Applying lessons learned from cytomegalovirus infection in transplant patients to vaccine design. Drug Discov Today. 2016 Apr;21(4):674-81.
PUBMED DOIUse of antibodies neutralizing epithelial cell infection to diagnose patients at risk for CMV Disease after transplantation.
Blanco-Lobo P, Cordero E, Martín-Gandul C, Gentil MA, Suárez-Artacho G, Sobrino M, Aznar J, Pérez-Romero P*. Use of antibodies neutralizing epithelial cell infection to diagnose patients at risk for CMV Disease after transplantation. J Infect. 2016 May;72(5):597-607.
PUBMED DOITiming of CMV-specific effector memory T cells predicts viral replication and survival after allogeneic hematopoietic stem cell transplantation.
Espigado I, de la Cruz-Vicente F, BenMarzouk-Hidalgo OJ, Gracia-Ahufinger I, Garcia-Lozano JR, Aguilar-Guisado M, Cisneros JM, Urbano-Ispizua A, Perez-Romero P*. Timing of CMV-specific effector memory T cells predicts viral replication and survival after allogeneic hematopoietic stem cell transplantation. Transpl Int. 2014 Dec;27(12):1253-62.
PUBMED DOIClinical impact of neutropenia related with the preemptive therapy of CMV infection in solid organ transplant recipients.
Martín-Gandul C, Pérez-Romero P*, González-Roncero FM, Berdaguer S, Gómez MA, Lage E, Sánchez M, Cisneros JM, Cordero E; Spanish Network for Research in Infectious Diseases REIPI. Clinical impact of neutropenia related with the preemptive therapy of CMV infection in solid organ transplant recipients. J Infect. 2014 Nov;69(5):500-6.
PUBMED DOIViral load, CMV-specific T-cell immune response and cytomegalovirus disease in solid organ transplant recipients at higher risk for cytomegalovirus infection during preemptive therapy.
Martín-Gandul C, Pérez-Romero P*, Blanco-Lobo P, Benmarzouk-Hidalgo OJ, Sánchez M, Gentil MA, Bernal C, Sobrino JM, Rodríguez-Hernández MJ, Cordero E; Spanish Network for Research in Infectious Diseases (REIPI). Viral load, CMV-specific T-cell immune response and cytomegalovirus disease in solid organ transplant recipients at higher risk for cytomegalovirus infection during preemptive therapy. Transpl Int. 2014 Oct;27(10):1060-8.
PUBMED DOIHCV eradication with IFN-based therapy does not completely restore gene expression in PBMCs from HIV/HCV-coinfected patients.
9. Brochado O, Martínez I (*), Berenguer J, Medrano L, González-García J, Jiménez-Sousa MA, Carrero A, Hontañón V, Navarro J, Guardiola JM, Pérez-Latorre L, Micán R, Fernández-Rodríguez A (‡), Resino S (* ‡). HCV eradication with IFN-based therapy does not completely restore gene expression in PBMCs from HIV/HCV-coinfected patients. J Biomed Sci 2021; 28:23 (A; FI= 12.77; D1, Medicine, Research & Experimental; JCR 2021).
PUBMED DOIDynamics of HIV Reservoir and HIV-1 Viral Splicing in HCV-Exposed Individuals after Elimination with DAAs or Spontaneous Clearance.
Martínez-Román P, Crespo-Bermejo C, Valle-Millares D, Lara-Aguilar V, Arca-Lafuente S, Martín-Carbonero, Ryan P, De los Santos I, López-Huertas MR, Palladino C, Muñoz-Muñoz M, Fernández-Rodríguez A*, Coiras M, Briz V, on behalf of COVIHEP network. Dynamics of HIV Reservoir and HIV-1 Viral Splicing in HCV-Exposed Individuals after Elimination with DAAs or Spontaneous Clearance. Journal of Clinical Medicine 2022, 11: 3579.
PUBMED DOIProtein Saver® cards: the best alternative for DBS storage at room temperature for HCV RNA.
Arca-Lafuente S, Casanueva-Benítez C, Crespo-Bermejo C, Lara-Aguilar V, Martín-Carbonero L, De los Santos I, Madrid R, Briz V*. Protein Saver® cards: the best alternative for DBS storage at room temperature for HCV RNA. 903 Scientific Report 2022, 12: 10124.
PUBMED DOIDiarrhoea-causing enteric protist species in intensively and extensively raised pigs (Sus scrofa domesticus) in Southern Spain. Part II: Association with Hepatitis E virus susceptibility.
Rivero-Juarez A, Dashti A, Santín M, George, Köster PC, Lopez-Lopez P, Risalde MA, García-Bocanegra I, Gomez-Villamandos JC, Caballero-Gómez J, Frías M, Bailo B, Ortega S, Muadica AS, Calero-Bernal R, González-Barrio D, Rivero A, Briz V*, Carmena D. Diarrhoea-causing enteric protist species in intensively and extensively raised pigs (Sus scrofa domesticus) in Southern Spain. Part II: Association with Hepatitis E virus susceptibility. Transboundary and Emerging Diseases 2021, 69: e1172-e1178.
PUBMED DOIHepatitis C virus influences HIV-1 viral splicing in coinfected patients.
Martínez-Román P, López-Huertas MR, Crespo-Bermejo C, Arca-Lafuente S, Cortegano I, Valle-Millares D, Gaspar ML, Martín-Carbonero, Domínguez-Domínguez L, Ryan P, De los Santos I, De la Fuente Moral S, Fernández-Rodríguez A, Coiras M, Briz V, on behalf of COVIHEP. Hepatitis C virus influences HIV-1 viral splicing in coinfected patients. J Clin Med 2020, 9 (7): 2091.
PUBMED DOIrotist enteroparasites in wild boar (Sus scrofa ferus) and black Iberian pig (Sus scrofa domesticus) in southern Spain: a protective effect on hepatitis E acquisition?
Rivero-Juárez A, Dashti A, López-López P, Salimo Muadica A, Risalde MA, Köster PC, Machuca I, Bailo B, Hernández de Mingo M, Dacal E, García-Bocanegra I, Saugar JM, Calero-Bernal R, González-Barrio D, Rivero A, Briz V, Carmena D. Protist enteroparasites in wild boar (Sus scrofa ferus) and black Iberian pig (Sus scrofa domesticus) in southern Spain: a protective effect on hepatitis E acquisition? Parasites & Vectors 2020, 13: 281
PUBMED DOIEpidemiological trend of hepatitis C-related liver events in Spain (2000-2015): A nationwide population-based study.
7. Rivero-Juárez A, Dashti A, López-López P, Salimo Muadica A, Risalde MA, Köster PC, Machuca I, Bailo B, Hernández de Mingo M, Dacal E, García-Bocanegra I, Saugar JM, Calero-Bernal R, González-Barrio D, Rivero A, Briz V, Carmena D. Protist enteroparasites in wild boar (Sus scrofa ferus) and black Iberian pig (Sus scrofa domesticus) in southern Spain: a protective effect on hepatitis E acquisition? Parasites & Vectors 2020, 13: 281
PUBMED DOIMultidisciplinary Group of viral coinfection HIV/Hepatitis (COVIHEP). HCV-coinfection is related to an increased HIV-1 reservoir size in cART-treated HIV patients: a cross-sectional study.
López-Huertas MR, Palladino C, Garrido-Arquero M, Esteban-Cartelle B, Sánchez-Carrillo M, Martínez-Román P, Martín-Carbonero L, Ryan P, Domínguez-Domínguez L, Santos ID, Moral SDLF, Benito JM, Rallón N, Alcamí J, Resino S, Fernández-Rodríguez A, Coiras M, Briz V*, on behalf of the Multidisciplinary Group of viral coinfection HIV/Hepatitis (COVIHEP). HCV-coinfection is related to an increased HIV-1 reservoir size in cART-treated HIV patients: a cross-sectional study. Sci Rep 2019: 9 (1); 5606.
PUBMED DOIPersistent Low-Level Viremia in treatment HIV infection: An unresolved status.
3. Crespo-Bermejo C, Ramírez de Arellano E, Lara-Aguilar V, Martínez-Román P, Arca Lafuente S, Gómez-Lus ML, Martín-Carbonero L, Briz V. Persistent Low-Level Viremia in treatment HIV infection: An unresolved status. Virulencia 2021, 12: 2919-2931.
PUBMED DOIFull coding hepatitis E virus genotype 3 genome amplification method.
Muñoz-Chimeno M, Forero JE, Echevarría JM, Muñoz-Bellido JL, Vázquez-López L, Morago L, García-Galera MC, Avellón A. Full coding hepatitis E virus genotype 3 genome amplification method. J Virol Methods. 2016 Apr;230:18-23.
PUBMED DOIComparative sensitivity of commercial tests for hepatitis E genotype 3 virus antibody detection.
• Avellón A, Morago L, García-Galera del Carmen M, Muñoz M, Jose-Manuel Echevarría JM. Comparative sensitivity of commercial tests for hepatitis E genotype 3 virus antibody detection. J Med Virol. 2015 Nov;87(11):1934-9.
PUBMED DOIEpidemiology and predictive factors for early and late mortality in Candida bloodstream infections: a population-based surveillance in Spain
11: Puig-Asensio M, Padilla B, Garnacho-Montero J, Zaragoza O, Aguado JM, Zaragoza R, Montejo M, Muñoz P, Ruiz-Camps I, Cuenca-Estrella M, Almirante B; CANDIPOP Project; GEIH-GEMICOMED (SEIMC); REIPI. Epidemiology and predictive factors for early and late mortality in Candida bloodstream infections: a population-based surveillance in Spain. Clin Microbiol Infect. 2014 Apr;20(4):O245-54.
PUBMED DOIB Pérez de Val, B Romero, MT Tórtola, L Herrera-León, P Pozo, I Mercader, JL Sáez, M Domingo, E Vidal. Poly-resistant Mycobacterium bovis infection in a human and sympatric sheep, Spain, 2017-2018
B Pérez de Val, B Romero, MT Tórtola, L Herrera-León, P Pozo, I Mercader, JL Sáez, M Domingo, E Vidal. Poly-resistant Mycobacterium bovis infection in a human and sympatric sheep, Spain, 2017-2018. Emerg Infect Dis. 2021 Apr;27(4):1241-1243. doi: 10.3201/eid2704.204467. PMID: 33755008.
DOIL Bernal-Martínez; L Herrera-Leon; C Valero; P de la Cruz; L Ghimpu; AC Mesa-Arango; G Santoni; L Goterris; R Millán; MJ Buitrago. Differential Diagnosis of Fungal Pneumonias vs.Tuberculosis in AIDS Patients by Using Two New Molecular Methods.
L Bernal-Martínez; L Herrera-Leon; C Valero; P de la Cruz; L Ghimpu; AC Mesa-Arango; G Santoni; L Goterris; R Millán; MJ Buitrago. Differential Diagnosis of Fungal Pneumonias vs.Tuberculosis in AIDS Patients by Using Two New Molecular Methods. J. Fungi 2021, 7, 336. doi.org: 10.3390/jof7050336. PMID: 33925404.
DOIE Tagliani, RAnthony, TA Kohl, A de Neeling, V Nikolayevskyy, C Ködmön, FP Maurer, S Niemann, D van Soolingen, MJ van der Werf, D Cirillo, ECDC molecular surveillance project participants. Use of a whole genome sequencing-based approach for Mycobacterium tuberculosis surveillance in Europe in 2017-2019: an ECDC pilot study
E Tagliani, RAnthony, TA Kohl, A de Neeling, V Nikolayevskyy, C Ködmön, FP Maurer, S Niemann, D van Soolingen, MJ van der Werf, D Cirillo, ECDC molecular surveillance project participants. Use of a whole genome sequencing-based approach for Mycobacterium tuberculosis surveillance in Europe in 2017-2019: an ECDC pilot study. Eur Respir J. 2021 Jan 5;57(1):2002272. doi: 10.1183/13993003.02272-2020. Print 2021 Jan. PMID: 32732329.
DOIMJ Iglesias, D Ibarz, A Cebollada, J Comín, MS Jiménez, MC Vázquez, S Samper, Spanish Working Group on MDRTB. The value of the continuous genotyping of multidrug resistant tuberculosis over 20 years in Spain.
MJ Iglesias, D Ibarz, A Cebollada, J Comín, MS Jiménez, MC Vázquez, S Samper, Spanish Working Group on MDRTB. The value of the continuous genotyping of multidrug resistant tuberculosis over 20 years in Spain. Sci Rep. 2020 Nov 24;10(1):20433. doi: 10.1038/s41598-020-77249-x. PMID: 33235225.
DOIS Campos-Gutierrez, MJ Ramos-Real, R Abreu, MS Jimenez, M Lecuona. Pseudo-ourbreak of Mycobacterium fortuitum, in a hospital bronchoscopy unit.
S Campos-Gutierrez, MJ Ramos-Real, R Abreu, MS Jimenez, M Lecuona. Pseudo-ourbreak of Mycobacterium fortuitum, in a hospital bronchoscopy unit. Am J Infect Control. 2020 Jul;48(7):765-769. doi: 10.1016/j.ajic.2019.11.019. Epub 2019 Dec 24. PMID: 31882175.
DOIGascha , Y Meijeb, M Espasac, B Fonta, MS Jiménez, N Fernández-Hidalgo. Disseminated Infection Due to Mycobacterium chimaera After Aortic Valve Replacement.
Gascha , Y Meijeb, M Espasac, B Fonta, MS Jiménez, N Fernández-Hidalgo. Disseminated Infection Due to Mycobacterium chimaera After Aortic Valve Replacement. Revista Española de cardiología. 2019. Vol 72 (6):502-503. DOI: 10.1016/j.rec.2018.06.026. PMID: 30029979
DOIPBMCs gene expression signature of advanced cirrhosis with high risk for clinically significant portal hypertension in HIV/HCV coinfected patients: A cross-control study
2. Salgüero S, Brochado-Kith O, Virseda Verdices A, Berenguer J, González-García J, Martínez I, Díez C, Hontañón V, Pérez-Latorre L, Fernández-Rodríguez A (‡), Jiménez-Sousa MA (‡,*), and Resino S (‡, *). PBMCs gene expression signature of advanced cirrhosis with high risk for clinically significant portal hypertension in HIV/HCV coinfected patients: A cross-control study. Biomed Pharmacother 2023, 159:114220. (A; FI= 7.42; D1, Pharmacology & Pharmacy; JCR 2021). PMID: 36628818. DOI: 10.1016/j.biopha.2023.114220.
PUBMEDLow anti-SARS-CoV-2 S antibody levels predict increased mortality and dissemination of viral components in the blood of critical COVID-19 patients
4. Martin-Vicente M, Almansa R, Martínez I, Tedim AP, Bustamante E, Tamayo L, Aldecoa C, Gómez JM, Renedo G, Berezo JA, Cedeño JA, Mamolar N, García Olivares P, Herrán-Monge R, Cicuendez R, Enríquez P, Ortega A, Jorge N, Doncel C, Fuente A, Bustamante-Munguira J, Muñoz-Gómez MJ, González-Rivera M, Puertas C, Más V, Vázquez M, Pérez-García F, Rico-Feijoo J, Martín S, Motos A, Fernandez-Barat L, Eiros JM, Domínguez-Gil M, Ferrer R, Barbé F, Trapiello W, Kelvin DJ (¥), Bermejo-Martin JF (* ¥), Resino S (¥), Torres A (* ¥). Low anti-SARS-CoV-2 S antibody levels predict increased mortality and dissemination of viral components in the blood of critical COVID-19 patients. J Intern Med. 2022, 291(2):232–240. (A; FI= 13.07; D1, Medicine, General & Internal; JCR 2021). PMID: 34611927. DOI: 10.1111/joim.13386.
PUBMEDPrevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort
5. Berenguer J (*), Díez C, Martín-Vicente M, Mican R, Pérez-Elías MJ, García-Fraile LJ, Vidal F, Suárez-García I, Podzamcer D, Del Romero J, Pulido F, Iribarren JA, Gutiérrez F, Poveda E, Galera C, Izquierdo R, Asensi V, Portilla J, López JC, Arribas JR, Moreno S, González-García J, Resino S (‡), Jarrín I (‡). Prevalence and factors associated with SARS-CoV-2 seropositivity in the Spanish HIV Research Network Cohort. Clin Microbiol Infect. 2021, 27(11):1678-1684. (A; FI= 13.31; D1, Microbiology; JCR 2021). PMID: 34186209 DOI: 10.1016/j.cmi.2021.06.023.
PUBMEDEnvironmental factors linked to hospital admissions in young children due to acute viral lower respiratory infections: A bidirectional case-crossover study
6. Álvaro-Meca A, Goez MC, Resino R, Matías V, Sepúlveda-Crespo D; Martínez I, Resino S (*). Environmental factors linked to hospital admissions in young children due to acute viral lower respiratory infections: a bidirectional case-crossover study. Environ Res. 2022. 212(Pt B), 113319. (A; FI= 8.43; D1, Public, Environmental & Occupational Health; JCR 2021). PMID: 35447151. DOI: 10.1016/j.envres.2022.113319.
PUBMEDDetection of active hepatitis C in a single visit and linkage to care among marginalized people using a mobile unit in Madrid, Spain
7. Ryan P, Valencia J, Cuevas G, Torres-Macho J, Troya J, Pueyo A, Muñoz-Gómez MJ, Muñoz-Rivas N, Vázquez-Morón S, Martínez, I, Lazarus JV, Resino S (*). Detection of active hepatitis C in a single visit and link-to-care among excluded people using a mobile unit in Madrid, Spain. Int J Drug Policy. 2021, 96:103424. (A; FI= 5.93; Q1, Substance Abuse; JCR 2021). PMID: 34429222 DOI: 10.1016/j.drugpo.2021.103424.
PUBMEDMaría José Ruiz-Lopéz, Milagros Muñoz-Chimeno, Jordi Figuerola, Ana M. Gavilán, Sarai Varona, Isabel Cuesta, Josué Martínez-de la Puente, Angel Zaballos, Francisca Molero, Ramón C. Soriguer, Mª Paz Sánchez-Seco, Santiago Ruiz, Ana Vázquez. Genomic analysis of West Nile virus lineage 1 isolated from mosquitoes
María José Ruiz-Lopéz, Milagros Muñoz-Chimeno, Jordi Figuerola, Ana M. Gavilán, Sarai Varona, Isabel Cuesta, Josué Martínez-de la Puente, Angel Zaballos, Francisca Molero, Ramón C. Soriguer, Mª Paz Sánchez-Seco, Santiago Ruiz, Ana Vázquez. Genomic analysis of West Nile virus lineage 1 isolated from mosquitoes from 2020-2021 outbreak occurred in Andalusia, Spain. Viruses 2023, 15, 266. https://doi.org/10.3390/v15020266
DOIJordi Figuerola, Miguel Ángel Jiménez-Clavero, María José Ruíz-López, Francisco Llorente, Santiago Ruiz, Andreas Hoefer, Pilar Aguilera-Sepúlveda, Jéssica Jiménez Peñuela1, Olaya García-Ruiz, Laura Herrero, Ramón C. Soriguer, Raúl Fernández Delgado, Mari Paz Sánchez-Seco, Josué Martínez-de la Puente, Ana Vázquez. A One Health view of the West Nile virus outbreak in Andalusía (Spain) in 2020
Jordi Figuerola, Miguel Ángel Jiménez-Clavero, María José Ruíz-López, Francisco Llorente, Santiago Ruiz, Andreas Hoefer, Pilar Aguilera-Sepúlveda, Jéssica Jiménez Peñuela1, Olaya García-Ruiz, Laura Herrero, Ramón C. Soriguer, Raúl Fernández Delgado, Mari Paz Sánchez-Seco, Josué Martínez-de la Puente, Ana Vázquez. A One Health view of the West Nile virus outbreak in Andalusía (Spain) in 2020. Emerg Microbes Infect. 2022 Dec;11(1):2570-2578. doi: 10.1080/22221751.2022.2134055.
DOIContent with Investigacion .
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José Enrique Yuste Lobo
Científico Titular
ORCID code: 0000-0001-7996-0837
Licenciado en Farmacia en 1998 y Doctor en 2002 por la Universidad Complutense de Madrid. Realizó su tesis doctoral en el laboratorio de neumococos del Centro Nacional de Microbiología del ISCIII. Posteriormente trabajó durante 5 años en Londres, primero como Investigador Asociado en el Centre for Molecular Microbiology and Infection Biology de Imperial College hasta 2003 y luego en el Centre for Respiratory Research de University College hasta 2007. Tras esta etapa posdoctoral en Reino Unido, trabajó durante 3 años como Investigador Senior en el Centro de Investigaciones Biológicas del CSIC hasta 2010. Desde entonces trabaja como Científico Titular en la Unidad de Neumococos del CNM-ISCIII, siendo el responsable científico del laboratorio desde el año 2016. Es investigador principal del grupo CIBER de Enfermedades Respiratorias (CIBERES) CB06/06/0003 (https://www.ciberes.org/grupos/grupo-de-investigacion?id=18143)
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Aída Úbeda Trillo
Técnico de Laboratorio
Técnico superior en laboratorio de diagnóstico clínico en 2019. Lleva vinculada a la Unidad de Neumococos desde 2023 como técnico de laboratorio contratada. Anteriormente estuvo contratada en el Servicio de Microbiología y Urgencias del Hospital Infanta Sofía de Madrid.
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Mirian Domenech Luchas
Investigadora posdoctoral
ORCID code: 0000-0002-0942-8180
Licenciada en Ciencias Biológicas en 2005 y Doctora en 2012 por la Universidad Complutense de Madrid. Realizó su tesis doctoral en el Centro de Investigaciones Biológicas del CSIC bajo la dirección del Profesor Ernesto García y la Dra. Miriam Moscoso caracterizando el biofilm neumocócico y estudiando distintos antimicrobianos para prevenir y tratar las infecciones producidas por neumococo y otros patógenos. Posteriormente ha trabajado como investigadora junior para el CIBER de Enfermedades Respiratorias y para la empresa Investigación y Proyectos Microbiológicos realizando estudios sobre biofilms de patógenos respiratorios. A finales del 2018 se incorporó a la Unidad de Neumococos del Centro Nacional Microbiología del ISCIII, donde participa en las distintas labores de investigación y referencia de la Unidad y es profesora ayudante Doctor de la Facultad de Biología de la Universidad Complutense de Madrid.
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Julio Sempere García
Investigador Posdoctoral
ORCID code: 0000-0001-9340-6867
Graduado en Bioquímica por la Universidad Complutense de Madrid, donde posteriormente cursó estudios de Máster en Microbiología y Parasitología. Actualmente realiza el programa de doctorado en Microbiología y Parasitología. Lleva asociado a la Unidad de Neumococos desde 2017, donde realizó las prácticas extracurriculares de grado y posteriormente realizó su trabajo de fin de grado (2018) y trabajo de fin de máster (2019). En 2022 obtuvo el grado de Doctor y actualmente investiga biofilms de bacterias Gram positivas, la matriz de estos y cómo interaccionan con el sistema inmune. También trabaja en la interacción de diferentes cápsulas de Streptococcus pneumoniae con el sistema inmune y patogénesis de serotipos emergentes incluidos en las futuras vacunas antineumocócicas.
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Covadonga Pérez García
Contratada predoctoral FPU
ORCID code: 0000-0002-5295-6480
Graduada en Biología por la Universidad Complutense de Madrid, donde posteriormente cursó estudios de Máster en Microbiología y Parasitología. Lleva vinculada a la Unidad de Neumococos desde 2019, donde realizó las prácticas extracurriculares de grado y posteriormente realizó su trabajo de fin de grado (2020) y trabajo de fin de máster (2021). En 2022 obtuvo beca predoctoral del programa FPU y actualmente investiga mecanismos de patogenicidad y protección de serotipos emergentes de neumococo.
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Erick Joan Vidal Alcántara
Ayudante de Investigación
ORCID code: 0000-0001-8946-3754
Graduado en Biología por la Universidad Complutense de Madrid, y posteriormente cursó estudios de Máster en Microbiología aplicada a salud pública e investigación en enfermedades infecciosas por la Universidad de Alcalá de Henares. Lleva vinculado a la Unidad de Neumococos desde 2022 como ayudante de investigación y es personal de plantilla.
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Inés Pareja Cerbán
Estudiante predoctoral CIBERES
ORCID code: 0009-0006-8015-7367
Graduada en Bioquímica por la Universidad de Málaga. Es contratada predoctoral del CIBER de Enfermedades Respiratorias (CIBERES) y en nuestro grupo está realizando su Tesis Doctoral en la caracterización de factores de virulencia de aislados prevalentes así como en el estudio y caracterización de nuevos antimicrobianos frente a bacterias respiratorias.
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Mirella Llamosí Fornés
Contratada predoctoral
ORCID code: 0000-0002-4369-9558
Graduada en Biología por la Universidad Complutense de Madrid, donde posteriormente cursó estudios de Máster en Microbiología y Parasitología. Está realizando su Tesis Doctoral en el campo de la resistencia antibiótica así como en la búsqueda y caracterización de nuevos antimicrobianos con especial interés en lograr compuestos activos frente a infecciones producidas por biofilms.
List of staff
Información adicional
The activities of the HIV viral and biology unit (UBVVIH) include research, service to the National Health System (NHS) and the administration of Justice and teaching. Its main lines of research are molecular epidemiology and HIV-1 phylogeny, in which the UBVVIH has carried out numerous national and international collaborations, focusing on the identification of viral genetic forms and the study of their correlations with epidemiological variables. Related lines are phylodynamics and phylogeography, which study the origin and dynamics of growth and spread of HIV-1 variants. Such studies can be used to better understand the evolution of the epidemic and to plan public health actions.
The UBVHIV also produces and characterises primary isolates and functional clones of the envelope of various genetic forms of HIV-1, which are deposited in repositories and used by numerous international groups. Other lines of research are described in the corresponding section. In terms of service to the NHS, the UBVVIH carries out antiretroviral resistance tests and prediction of tropism as a therapeutic guide in HIV-1 infected patients. As for its collaboration with the Justice Administration, the UBVVIH carries out expert opinions through phylogenetic studies of sequences for legal cases of possible HIV transmissions.